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Protein Kinase C-Dependent and -Independent Pathways Mediate Epidermal Growth Factor (EGF) Effects in Human Endometrial Adenocarcinoma Cell Line KLE

dc.contributor.authorGretz, III, Herbert F.en_US
dc.contributor.authorTalavera, Franciscoen_US
dc.contributor.authorConnor, Patricken_US
dc.contributor.authorPearl, Michael L.en_US
dc.contributor.authorLelle, Ralph J.en_US
dc.contributor.authorRoberts, James A.en_US
dc.contributor.authorMenon, K. M. J.en_US
dc.date.accessioned2006-05-10T15:41:52Z
dc.date.available2006-05-10T15:41:52Z
dc.date.issued1994-05en_US
dc.identifier.citationGretz, III, Herbert F., Talavera, Francisco, Connor, Patrick, Pearl, Michael, Lelle, Ralph J., Roberts, James A., Menon, K. M. J. (1994/05)."Protein Kinase C-Dependent and -Independent Pathways Mediate Epidermal Growth Factor (EGF) Effects in Human Endometrial Adenocarcinoma Cell Line KLE." Gynecologic Oncology 53(2): 228-233. <http://hdl.handle.net/2027.42/31609>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG6-45NK017-8K/2/3cccac1b02315663d34b4d07681801b5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31609
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8188084&dopt=citationen_US
dc.description.abstractThe role of EGF in the proliferation of the poorly differentiated endometrial adenocarcinoma cell line (KLE) was examined. EGF (10 ng/ml) and the tumor promoter, protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA) were potent stimulators (P 3H]thymidine incorporation into DNA. Staurosporine, a protein kinase C inhibitor, partially blocked the EGF effects on [3H]thymidine incorporation. Similarly, downregulation of protein kinase C also failed to completely abolish EGF effect on DNA synthesis and cell division. These results suggest that in the KLE cell line EGF stimulation of cell growth is exerted through both protein kinase C-dependent and -independent pathways.en_US
dc.format.extent6 bytes
dc.format.extent3118 bytes
dc.format.extent329171 bytes
dc.format.mimetypetext/plain
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.titleProtein Kinase C-Dependent and -Independent Pathways Mediate Epidermal Growth Factor (EGF) Effects in Human Endometrial Adenocarcinoma Cell Line KLEen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbsecondlevelOphthalmologyen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbsecondlevelObstetrics and Gynecologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University, of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University, of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University, of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University, of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University, of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University, of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Obstetrics and Gynecology, University, of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.identifier.pmid8188084en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31609/3/0000538.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/gyno.1994.1120en_US
dc.identifier.sourceGynecologic Oncologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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