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Direct optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatography
dc.contributor.authorGildersleeve, David L.en_US
dc.contributor.authorJung, Yong-Woonen_US
dc.contributor.authorWieland, Donald M.en_US
dc.date.accessioned2006-04-10T18:12:31Z
dc.date.available2006-04-10T18:12:31Z
dc.date.issued1994-04-29en_US
dc.identifier.citationGildersleeve, David L., Jung, Yong-Woon, Wieland, Donald M. (1994/04/29)."Direct optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatography." Journal of Chromatography A 667(1-2): 183-189. <http://hdl.handle.net/2027.42/31629>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TG8-44HTG67-1V/2/1cb4380588db8515b38ed6a195c68b0aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31629
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8025628&dopt=citationen_US
dc.description.abstractThe direct optical resolution of the vesicular acetylcholine uptake inhibitors vesamicol and benzovesamicol and nine benzovesamicol analogues were performed by HPLC on a commercially available cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase. Separation of each enantiomeric pair was optimized with respect to solvent strength and flow-rate, using mobile phase mixtures of hexane-2-propanol-diethylamine. The method has been successfully applied to the analysis of the optical purity of benzovesamicol intermediates and products, including (-)-5-[123I]iodobenzovesamicol which is currently undergoing clinical evaluation as a tracer for mapping central cholinergic neurons, and the purification of both antipodes of ( +/-)-7-[125I]iodobenzovesamicol.en_US
dc.format.extent562200 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDirect optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatographyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, USAen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, USAen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, USAen_US
dc.identifier.pmid8025628en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31629/1/0000563.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0021-9673(94)89066-8en_US
dc.identifier.sourceJournal of Chromatography Aen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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