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Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia,

dc.contributor.authorDeQuardo, John R.en_US
dc.contributor.authorTandon, Rajiven_US
dc.contributor.authorGoldman, Robert S.en_US
dc.contributor.authorMeador-Woodruff, James H.en_US
dc.contributor.authorMcGrath-Giroux, Marleneen_US
dc.contributor.authorBrunberg, James A.en_US
dc.contributor.authorKim, Lorraineen_US
dc.date.accessioned2006-04-10T18:12:59Z
dc.date.available2006-04-10T18:12:59Z
dc.date.issued1994-04-15en_US
dc.identifier.citationDeQuardo, John R., Tandon, Rajiv, Goldman, Robert, Meador-Woodruff, James H., McGrath-Giroux, Marlene, Brunberg, James A., Kim, Lorraine (1994/04/15)."Ventricular enlargement, neuropsychological status, and premorbid function in schizophrenia,." Biological Psychiatry 35(8): 517-524. <http://hdl.handle.net/2027.42/31637>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4S-484N7RR-PK/2/f0cc466934c11def077ca6774789486den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31637
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8038295&dopt=citationen_US
dc.description.abstractVentricular enlargement is one of the most consistently documented neurobiological abnormalities in schizophrenia. The timing of the development of this abnormality in the course of schizophrenic illness and its relationship to neuropsychological dysfunction and premorbid adjustment is, however, unclear. To address these questions, we examined the relationship between ventricle-brain ration (VBR), premorbid adjustment, and neuropsychological function, in 23 acutely exacerbated chronic schizophrenic inpatients. We obserged that larger ventricles were associated with better current neuropsychological test performance, better premorbid cognitive ability, greater cognitive deterioration, better childhood premorbid social function, and greater decline in social function from premorbid levels. These data suggest that at least two developmental processes may operate in the genesis of cognitive and social dysfunction in schizophrenia: (1) childhood onset associated with poor premorbid childhood function, low educational achievement, lower intelligence quotient (IQ) and variably with VBR; and (2) adolescent onset associated with relatively normal childhood social function, higher academic achievement and IQ and increased VBR. Ventricular enlargement may reflect a late developmental or degenerative pathological process in schizophrenia.en_US
dc.format.extent957787 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleVentricular enlargement, neuropsychological status, and premorbid function in schizophrenia,en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumSchizophrenia Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumSchizophrenia Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumSchizophrenia Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumSchizophrenia Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumSchizophrenia Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumSchizophrenia Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumSchizophrenia Program, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.identifier.pmid8038295en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31637/1/0000571.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-3223(94)90098-1en_US
dc.identifier.sourceBiological Psychiatryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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