Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea
dc.contributor.author | Bacon, III, Alfred E. | en_US |
dc.contributor.author | Fekety, F. Robert | en_US |
dc.date.accessioned | 2006-04-10T18:14:27Z | |
dc.date.available | 2006-04-10T18:14:27Z | |
dc.date.issued | 1994-04 | en_US |
dc.identifier.citation | Bacon, III, Alfred E., Fekety, Robert (1994/04)."Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea." Diagnostic Microbiology and Infectious Disease 18(4): 205-209. <http://hdl.handle.net/2027.42/31662> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T60-476TVR0-48/2/246bfedf52020ff234ebb56067659eec | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31662 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7924215&dopt=citation | en_US |
dc.description.abstract | Serum immunoglobulin G (IgG) class antibodies directed against toxins A and B of Clostridium difficile were studied using an enzyme-linked immunosorbent assay and a serum-neutralizing assay based on the MRC-5 tissue cytotoxicity assay. Of 185 individuals, 46 sera (24%) in the general population demonstrated IgG antibody, 36 (19.4%) against toxin A and 15 (8.1%) against toxin B. Antibody titer in the general population did not correlate with serum-neutralizing activity. Antibody prevalence fell with age (P = 0.58) over 50 years. Six of ten patients with acute primary episodes of C. difficile-associated diarrhea demonstrated antibody in convalescentphase sera, predominantly directed against toxin B. Only two (28%) of seven patients with a history of relapsing C. difficile disease had demonstrable antibody. | en_US |
dc.format.extent | 448114 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | From the Division of Infectious Diseases, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | From the Division of Infectious Diseases, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 7924215 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31662/1/0000596.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0732-8893(94)90021-3 | en_US |
dc.identifier.source | Diagnostic Microbiology and Infectious Disease | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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