The Human 4F2 Antigen: Evidence for Cryptic and Noncryptic Epitopes and for a Role of 4F2 in Human T Lymphocyte Activation
dc.contributor.author | Friedman, Alan W. | en_US |
dc.contributor.author | Diaz, Jr. , Luis A. | en_US |
dc.contributor.author | Moore, Susan | en_US |
dc.contributor.author | Schaller, Jill | en_US |
dc.contributor.author | Fox, David A. | en_US |
dc.date.accessioned | 2006-04-10T18:14:51Z | |
dc.date.available | 2006-04-10T18:14:51Z | |
dc.date.issued | 1994-04-01 | en_US |
dc.identifier.citation | Friedman, Alan W., Diaz, Jr., Luis A., Moore, Susan, Schaller, Jill, Fox, David A. (1994/04/01)."The Human 4F2 Antigen: Evidence for Cryptic and Noncryptic Epitopes and for a Role of 4F2 in Human T Lymphocyte Activation." Cellular Immunology 154(2): 253-263. <http://hdl.handle.net/2027.42/31669> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCF-45P0W2H-83/2/45fd3cbf5f18a60e1676fe2f0f870c73 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31669 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7510581&dopt=citation | en_US |
dc.description.abstract | T lymphocyte activation can be triggered through multiple distinct, but functionally related, pathways. Murine monoclonal antibodies (mAbs) have been used to characterize the surface components of several of these pathways, as well as structures whose function is not yet known. One such cell surface structure is the heterodimeric 4F2 antigen, which is expressed on activated and proliferating cells. Two new mAbs that recognize the heavy chain of the 4F2 antigen have been produced in our laboratory. One antibody, UM7F8, is comitogenic with soluble anti-CD2 and immobilized (but not soluble) anti-CD3 mAbs. The second antibody, termed UM2G12, appears to recognize a cryptic epitope on the 4F2 heavy chain and is not comitogenic for T cells. In view of the functional effects seen with UM7F8, and the highly regulated expression of the 4F2 antigen, it seems likely that 4F2 has a specific role in T cell development and activation. | en_US |
dc.format.extent | 388421 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The Human 4F2 Antigen: Evidence for Cryptic and Noncryptic Epitopes and for a Role of 4F2 in Human T Lymphocyte Activation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Division of Rheumatology, Specialized Center of Research in Rheumatoid Arthritis, Multipurpose Arthritis and Musculoskeletal Diseases Center, University of Michigan, Ann Arbor, Michigan 48109-0531 | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Division of Rheumatology, Specialized Center of Research in Rheumatoid Arthritis, Multipurpose Arthritis and Musculoskeletal Diseases Center, University of Michigan, Ann Arbor, Michigan 48109-0531 | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Division of Rheumatology, Specialized Center of Research in Rheumatoid Arthritis, Multipurpose Arthritis and Musculoskeletal Diseases Center, University of Michigan, Ann Arbor, Michigan 48109-0531 | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Division of Rheumatology, Specialized Center of Research in Rheumatoid Arthritis, Multipurpose Arthritis and Musculoskeletal Diseases Center, University of Michigan, Ann Arbor, Michigan 48109-0531 | en_US |
dc.contributor.affiliationum | Rackham Arthritis Research Unit, Division of Rheumatology, Specialized Center of Research in Rheumatoid Arthritis, Multipurpose Arthritis and Musculoskeletal Diseases Center, University of Michigan, Ann Arbor, Michigan 48109-0531 | en_US |
dc.identifier.pmid | 7510581 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31669/1/0000605.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/cimm.1994.1075 | en_US |
dc.identifier.source | Cellular Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.