Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig
dc.contributor.author | Juiz, Jose M. | en_US |
dc.contributor.author | Albin, Roger L. | en_US |
dc.contributor.author | Helfert, Robert H. | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.date.accessioned | 2006-04-10T18:17:05Z | |
dc.date.available | 2006-04-10T18:17:05Z | |
dc.date.issued | 1994-03-14 | en_US |
dc.identifier.citation | Juiz, Jose M., Albin, Roger L., Helfert, Robert H., Altschuler, Richard A. (1994/03/14)."Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig." Brain Research 639(2): 193-201. <http://hdl.handle.net/2027.42/31709> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-484FH7J-281/2/30feece46f79f9c17b51b04733fd5b15 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31709 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8205472&dopt=citation | en_US |
dc.description.abstract | We compared the distribution of GABAA and GABAB binding sites in the cochlear nucleus using quantitative receptor autoradiography with [3H]GABA. To visualize GABAA binding sites, GABAB binding sites were blocked with +/-baclofen. To visualize GABAB binding sites, isoguvacine was used to block GABAA binding sites. GABAA binding sites predominated over GABAB, although there were marked regional differences in the distribution of binding. In the ventral cochlear nucleus, GABAA and GABAB binding sites were concentrated in the peripheral granule cell cap, with low binding levels in the central region. In the dorsal cochlear nucleus, binding was concentrated in the superficial (fusiform and molecular) layers, with a distinct laminar pattern. GABAA binding sites predominated in the fusiform cell layer. The molecular layer contained the highest level of GABAB binding sites in the entire cochlear nucleus. These results suggest that GABAergic inhibition in the cochlear nucleus is mediated both by GABAA and GABAB receptors, particularly in the dorsal cochlear nucleus. However, low levels of binding in areas such as the magnocellular regions of the ventral cochlear nucleus, known to contain abundant GABAergic synapses, suggest heterogeneity of GABA receptors in this auditory nucleus. | en_US |
dc.format.extent | 823882 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Neurology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 8205472 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31709/1/0000645.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(94)91730-2 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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