Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs
dc.contributor.author | Zwemer, Charles F. | en_US |
dc.contributor.author | Whitesall, Steven E. | en_US |
dc.contributor.author | D'Alecy, Louis G. | en_US |
dc.date.accessioned | 2006-04-10T18:18:48Z | |
dc.date.available | 2006-04-10T18:18:48Z | |
dc.date.issued | 1994-03 | en_US |
dc.identifier.citation | Zwemer, Charles F., Whitesall, Steven E., D'Alecy, Louis G. (1994/03)."Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs." Resuscitation 27(2): 159-170. <http://hdl.handle.net/2027.42/31740> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T19-4C0R3J4-39/2/ebfe9f1835e534f8c05b532c32a6b514 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31740 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8086011&dopt=citation | en_US |
dc.description.abstract | This study investigated the effects of normoxic (FIO2 = 0.21), hyperoxic (FIO2 = 1.0), and hyperoxic (FIO2 = 1.0) plus antioxidant pretreatment (tirilizad mesylate) resuscitation on neurologic outcome following 9 min of normothermic (39 +/- 1.0[deg]C) cardiac arrest. Physiologic variables including arterial blood gases and neurologic outcome, which was assessed using a standardized scoring system, were followed over a 24-h period following resuscitation from cardiac arrest. Hyperoxically resuscitated dogs sustained significantly worse neurological deficit at 12 and 24 h (mean scores: 39 +/- 3 and 49 +/- 8, respectively) than did antioxidant pretreated hyperoxically resuscitated dogs (mean scores: 22 +/- 1, P = 0.0007 and 22 +/- 1, P = 0.004, respectively) and normoxically resuscitated dogs (mean scores: 28 +/- 4, P = 0.025 and 33 +/- 8, P = 0.041 respectively). These data suggest that oxidant injury has a major role in central nervous system dysfunction following successful resuscitation from 9 min of cardiac arrest. Also, resuscitation from cardiac arrest with hyperoxic FIO2's may contribute to and further exacerbate neurologic dysfunction. | en_US |
dc.format.extent | 1178259 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Family Medicine and Primary Care | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology and Surgery, 7703 Medical Science Building II, The University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA | en_US |
dc.contributor.affiliationum | Department of Physiology and Surgery, 7703 Medical Science Building II, The University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA | en_US |
dc.contributor.affiliationum | Department of Physiology and Surgery, 7703 Medical Science Building II, The University of Michigan Medical School, Ann Arbor, MI 48109-0622, USA | en_US |
dc.identifier.pmid | 8086011 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31740/1/0000679.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0300-9572(94)90009-4 | en_US |
dc.identifier.source | Resuscitation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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