Glycine-extended post-translational processing intermediates of gastrin and cholecystokinin in the gut
dc.contributor.author | Marino, Lucyndia | en_US |
dc.contributor.author | Muglia, Beatrice | en_US |
dc.contributor.author | Dickinson, Chris John | en_US |
dc.date.accessioned | 2006-04-10T18:21:02Z | |
dc.date.available | 2006-04-10T18:21:02Z | |
dc.date.issued | 1994-02-03 | en_US |
dc.identifier.citation | Marino, Lucyndia, Muglia, Beatrice, Dickinson, Chris J. (1994/02/03)."Glycine-extended post-translational processing intermediates of gastrin and cholecystokinin in the gut." Regulatory Peptides 50(1): 73-85. <http://hdl.handle.net/2027.42/31783> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0S-47GGSHP-4X/2/55b98b233f269d7fb9c471e70ab013fa | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31783 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8159808&dopt=citation | en_US |
dc.description.abstract | Cholecystokinin (CCK) and gastrin are two polypeptide hormones of the gut that share complete structural homology in their carboxyl-terminal pentapeptide. Both peptides are biologically activated from their glycine-extended precursor forms by a carboxyl-terminal [alpha]-amidation reaction. In the present studies we used region specific antisera to characterize the carboxyl-terminally amidated and glycine-extended forms of gastrin and CCK in mammalian intestine. Multiple amidated molecular forms of gastrin and CCK and their corresponding glycine-extended forms were detected throughout the most of the small bowel. Although, we detected substantial amounts of glycine-extended CCK in the proximal rat duodenum, we detected none of the corresponding amidated molecular forms. In contrast, the proximal duodenum of dog and hog contained both glycine-extended and amidated CCK. These findings suggest that there may be peptide, tissue and species specific differences in expression and activity of the peptide [alpha]-amidating enzyme. | en_US |
dc.format.extent | 944213 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Glycine-extended post-translational processing intermediates of gastrin and cholecystokinin in the gut | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Department of Pediatrics, Ann Arbor, MI 48109-0658, USA | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Department of Pediatrics, Ann Arbor, MI 48109-0658, USA | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Department of Pediatrics, Ann Arbor, MI 48109-0658, USA | en_US |
dc.identifier.pmid | 8159808 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31783/1/0000724.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0167-0115(94)90193-7 | en_US |
dc.identifier.source | Regulatory Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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