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Delayed Onset Hypertension with Infrarenal Aortic Cross-Clamping in Dogs

dc.contributor.authorMoursi, Mohammed M.en_US
dc.contributor.authorFacktor, Matthew A.en_US
dc.contributor.authorZelenock, Gerald B.en_US
dc.contributor.authorD'Alecy, Louis G.en_US
dc.date.accessioned2006-04-10T18:22:16Z
dc.date.available2006-04-10T18:22:16Z
dc.date.issued1994-02en_US
dc.identifier.citationMoursi, Mohammed M., Facktor, Matthew A., Zelenock, Gerald B., D'Alecy, Louis G. (1994/02)."Delayed Onset Hypertension with Infrarenal Aortic Cross-Clamping in Dogs." Journal of Surgical Research 56(2): 168-178. <http://hdl.handle.net/2027.42/31805>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WM6-45P0GBB-4W/2/7519e546b05f5adea610c3291db32374en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31805
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8121174&dopt=citationen_US
dc.description.abstractThe time course and mechanism of systemic hypertension associated with infrarenal aortic cross-clamping were investigated in 31 chloralose-anesthetized dogs after ligating the tail artery, the paired infrarenal lumbar arteries, and the circumflex iliac arteries bilaterally. Cardiac output, renal blood flow, and suprarenal and infrarenal mean arterial blood pressure were continuously monitored. Infrarenal aortic clamping (90 min) in the standard group (n = 6) consistently decreased infrarenal blood pressure from 90 +/- 6 to 13 +/- 1 mm Hg within 1 min, while suprarenal blood pressure gradually increased over 20-30 min from 88 +/- 7 to 144 +/- 8 mm Hg, where it remained until declamp. The SHAM group (identical operation and instrumentation, without aortic clamping) (n = 5) showed no statistically significant changes. After 90 min of clamp total peripheral and renal resistance nearly doubled but no statistically significant changes in cardiac output, heart rate, central venous pressure, renal blood flow, renin, or glomerular filtration rate were detected. Upon declamping, pressures returned to control levels within 20 min. Groups with bilateral nephrectomy (n = 9) or unilateral iliac artery clamping (n = 7) produced similar time courses and patterns of hemodynamic change. Ablation of afferent nerves from the left hind limb (n = 4) eliminated the hypertension produced by left iliac artery clamping. The substantial delay (20-30 min) to the onset and full development of suprarenal hypertension, with near immediate infrarenal hypotension, is not consistent with a direct mechanical impedance effect. Hypertension in the presence of a bilateral nephrectomy or unilateral iliac artery clamping combined with its full reversal by nerve section strongly suggests that this is a reflex hypertension. This reflex mechanism of hypertension development has implications for intra- or perioperative events associated with hypertension management.en_US
dc.format.extent691614 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDelayed Onset Hypertension with Infrarenal Aortic Cross-Clamping in Dogsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan Medical School, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid8121174en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31805/1/0000751.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/jsre.1994.1028en_US
dc.identifier.sourceJournal of Surgical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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