Synthesis and in vivo evaluation of a 99m/99Tc-DADT-Benzovesamicol: a potential marker for cholinergic neurons
dc.contributor.author | Del Rosario, Renato B. | en_US |
dc.contributor.author | Jung, Yong-Woon | en_US |
dc.contributor.author | Baidoo, Kwamena E. | en_US |
dc.contributor.author | Lever, Susan Z. | en_US |
dc.contributor.author | Wieland, Donald M. | en_US |
dc.date.accessioned | 2006-04-10T18:22:22Z | |
dc.date.available | 2006-04-10T18:22:22Z | |
dc.date.issued | 1994-02 | en_US |
dc.identifier.citation | Del Rosario, Renato B., Jung, Yong-Woon, Baidoo, Kwamena E., Lever, Susan Z., Wieland, Donald M. (1994/02)."Synthesis and in vivo evaluation of a 99m/99Tc-DADT-Benzovesamicol: a potential marker for cholinergic neurons." Nuclear Medicine and Biology 21(2): 197-203. <http://hdl.handle.net/2027.42/31807> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T9Y-4BXGNF7-1V/2/a440c2b19cc43b84f928e6217e24d8f2 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31807 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9234283&dopt=citation | en_US |
dc.description.abstract | The diaminodithiol (DADT) ligand has been conjugated to the neuromuscular blocking agent benzovesamicol (BVM) in the 5-position. DADT-BVM 1 was synthesized by coupling of 5-aminomethylbenzovesamicol with a BCA thiolactone reagent. 99mTc radiolabeling of 1 with [99mTc]glucoheptonate gave a 4.7:1 mixture of two 99mTc complexes as determined by HPLC. Biodistribution data of the major [99mTc]-1 complex in CD-1 mice (n = 4-5) showed very little uptake and no regional selectivity in the mouse brain. At all time points examined, the lung and liver showed the highest uptake. For whole brain, the % injected dose values were 0.27, 0.12, 0.04 and 0.01% at t = 1, 5, 30 and 240 min. The major [99mTc]-1 product exhibited a log P = 3.13 +/- 0.06 (SD) with an IC50 = 140-280 nM for the corresponding [99Tc]-1 vs ( - )-N-[3H]methyl-5-aminobenzovesamicol. The low brain uptake of [99mTc]-1 vs 5-iodobenzovesamicol is attributed to its higher molecular weight (752) and lower binding affinity. | en_US |
dc.format.extent | 712339 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Synthesis and in vivo evaluation of a 99m/99Tc-DADT-Benzovesamicol: a potential marker for cholinergic neurons | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationother | Division of Radiation Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, U.S.A. | en_US |
dc.contributor.affiliationother | Division of Radiation Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, U.S.A. | en_US |
dc.identifier.pmid | 9234283 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31807/1/0000753.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0969-8051(94)90009-4 | en_US |
dc.identifier.source | Nuclear Medicine and Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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