Magnetization transfer contrast imaging of hepatic neoplasms
dc.contributor.author | Hollett, Michael D. | en_US |
dc.contributor.author | Aisen, Alex M. | en_US |
dc.contributor.author | Yeung, Hong N. | en_US |
dc.contributor.author | Francis, Isaac R. | en_US |
dc.contributor.author | Bree, Robert L. | en_US |
dc.date.accessioned | 2006-04-10T18:24:21Z | |
dc.date.available | 2006-04-10T18:24:21Z | |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Hollett, Michael D., Aisen, Alex M., Yeung, Hong N., Francis, Isaac R., Bree, Robert L. (1994)."Magnetization transfer contrast imaging of hepatic neoplasms." Magnetic Resonance Imaging 12(1): 1-8. <http://hdl.handle.net/2027.42/31843> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T9D-4C3BXFC-1/2/4ebd407909cb0a591c42d7cd526f32e5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31843 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8295496&dopt=citation | en_US |
dc.description.abstract | A method of performing magnetization transfer contrast (MTC) using a pulse sequence based on a series of onresonance binomial pulses preceding a conventional spin-echo sequence has been recently described. We investigated this technique in the evaluation of circumscribed hepatic neoplasms on a 0.5T imager. Conventional spin-echo imaging was performed in 18 patients with hepatic neoplasms, 15 with primary or metastatic hepatic neoplasms, and 3 with cavernous hemangiomas. The T1-weighted sequence was repeated following MTC saturation in 7 patients and the proton density sequence was repeated following MTC saturation in 13 patients (both were used in two patients). The mean lesion-to-liver contrast for neoplasms worsened with T1-MTC (0.87 vs. 1.04), but improved slightly with proton density-MTC (1.10 vs. 1.22) when compared to the corresponding non-MTC spinecho images. However, these differences were not statistically significant (p = .19 and p = .16, respectively). The limited data on cavernous hemangiomas does not suggest these have consistently different MTC imaging characteristics from other hepatic neoplasms. In conclusion, MTC imaging using a binomial saturation pulse did not offer significant improvement in contrast between hepatic neoplasms and normal liver. Refinements of the binomial pulse sequence will be necessary if a consistent improvement in lesion sensitivity is to be achieved. Evaluation of its role in increasing diagnostic specificity will require further investigation. | en_US |
dc.format.extent | 867309 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Magnetization transfer contrast imaging of hepatic neoplasms | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Family Medicine and Primary Care | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109-0030, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109-0030, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109-0030, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109-0030, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109-0030, USA | en_US |
dc.identifier.pmid | 8295496 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31843/1/0000790.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0730-725X(94)92346-9 | en_US |
dc.identifier.source | Magnetic Resonance Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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