Aging and immune function: Cellular and biochemical analyses
dc.contributor.author | Miller, Richard A. | en_US |
dc.date.accessioned | 2006-04-10T18:24:54Z | |
dc.date.available | 2006-04-10T18:24:54Z | |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Miller, Richard A. (1994)."Aging and immune function: Cellular and biochemical analyses." Experimental Gerontology 29(1): 21-35. <http://hdl.handle.net/2027.42/31853> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T6J-47RJ23R-X7/2/c0610495c88ba005f75e348ba6b77e39 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31853 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8187838&dopt=citation | en_US |
dc.description.abstract | Recent progress on the cellular and molecular basis for T cell dysfunction in aged mice is reviewed, with emphasis on defects in calcium signal generation and protein kinase function. The accumulation in older mice of memory T cells at the expense of naive T cells seems to account for most of the decline in the proportion of cells that can secrete or respond to interleukin 2. Memory T cells in mice of any age have an intrinsic resistance to increases in cytoplasmic free calcium ion concentration, which in turn interferes with their responses to polyclonal activators. T cells from old mice also exhibit declines both in serine/threonine and in tyrosine-specific protein kinase signals after activation by either receptor-dependent or receptor-independent agonists. | en_US |
dc.format.extent | 1024826 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Aging and immune function: Cellular and biochemical analyses | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Institute of Gerontology, Ann Arbor VA Medical Center, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 8187838 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31853/1/0000803.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0531-5565(94)90060-4 | en_US |
dc.identifier.source | Experimental Gerontology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.