Maturity-onset diabetes of the young
dc.contributor.author | Fajans, Stefan S. | en_US |
dc.contributor.author | Bell, Graeme I. | en_US |
dc.contributor.author | Bowden, Donald W. | en_US |
dc.contributor.author | Halter, Jeffrey B. | en_US |
dc.contributor.author | Polonsky, Kenneth S. | en_US |
dc.date.accessioned | 2006-04-10T18:29:11Z | |
dc.date.available | 2006-04-10T18:29:11Z | |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Fajans, Stefan S., Bell, Graeme I., Bowden, Donald W., Halter, Jeffrey B., Polonsky, Kenneth S. (1994)."Maturity-onset diabetes of the young." Life Sciences 55(6): 413-422. <http://hdl.handle.net/2027.42/31930> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-478B2SG-1GV/2/537f4d50d36c168665acc037d80fc4be | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31930 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8035658&dopt=citation | en_US |
dc.description.abstract | Maturity-onset diabetes of the young (MODY) is a subtype of noninsulin dependent diabetes mellitus (NIDDM). It is characterized by an early age of onset and autosomal dominant mode of inheritance. These features and the availability of large multigenerational pedigrees make MODY useful for genetic studies of diabetes. In the large, 5-generational RW pedigree, MODY is tightly linked to genetic markers on chromosome 20q. Affected subjects in this family show abnormalities of carbohydrate metabolism varying from impaired glucose tolerance (IGT) to severe diabetes. Approximately 30% of diabetic subjects become insulin requiring and vascular complications occur. MODY is also linked to the glucokinase gene on chromosome 7p and many different mutations associated with MODY have been identified in this gene. MODY due to mutations in the glucokinase gene is a relatively mild form of diabetes with mild fasting hyperglycemia and IGT in the majority. It is rarely insulin requiring and rarely has vascular complications. Clinical studies indicate that the genetic or primary defect in MODY is characterized by deranged and deficient insulin secretion and not by insulin resistance and that there are quantitative and qualitative differences in insulin secretory defects which differentiate subjects with MODY due to glucokinase mutations from those with mutations in the gene on chromosome 20q. These differences correlate with the severity of diabetes between these two genetic forms of MODY. | en_US |
dc.format.extent | 721787 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Maturity-onset diabetes of the young | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, USA | en_US |
dc.contributor.affiliationum | Department of Biochemistry, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA; Department of Internal Medicine, University of Michigan Medical Center, USA. | en_US |
dc.contributor.affiliationother | Department of Veterans Affairs Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Chicago, IL, USA | en_US |
dc.identifier.pmid | 8035658 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31930/1/0000883.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(94)90052-3 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.