The substrate-facilitated transport of the glucose carrier across the human erythrocyte membrane

Abstract

1. 1. The rate of egress of glucose from human red blood cells into saline media either without sugar or containing glucose, galactose, sorbose or fructose has been determined at 25[deg] and for glucose or zero sugar at 0[deg].2. 2. From these data, using a simplified form of the theoretical analysis of 13, it is shown that the rate of movement across the membrane of the substrate-carrier complex is greater than that of the free carrier, that is, the movement of carrier is facilitated by the substrate.3. 3. A lower limit of 2.8 is derived for the ratio of these rates of movement.4. 4. Evidence is presented that the aldoses and ketoses share a common carrier.