The distribution, metabolism, and excretion of hydrazine in rat and mouse

Abstract

Approximately 50% of 40- and 60-mg doses of hydrazine per kilogram injected subcutaneously into mice was excreted unchanged in the urine within 48 hours. The present data also suggest that a relatively large amount of hydrazine is rapidly (0.5-2 hours) metabolized. Tissue analysis at 2 and 20 hours after the subcutaneous injection of hydrazine in rats indicated a rather uniform distribution throughout most tissues. Kidney concentration was considerably higher than other tissues while fat and brain contained comparatively low levels. Twenty hours after the injection, approximately 27% of the dose had been excreted in the urine and only 1.5% remained as free or reactive hydrazine in the tissues.