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Biochemical response to 1,1-dimethylhydrazine (UDMH)
dc.contributor.authorCornish, Herbert H.en_US
dc.contributor.authorBarth, Mary L.en_US
dc.date.accessioned2006-04-13T14:46:17Z
dc.date.available2006-04-13T14:46:17Z
dc.date.issued1964-09en_US
dc.identifier.citationCornish, Herbert H., Barth, Mary L. (1964/09)."Biochemical response to 1,1-dimethylhydrazine (UDMH)." Toxicology and Applied Pharmacology 6(5): 568-575. <http://hdl.handle.net/2027.42/32104>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WXH-4DBJ9NY-8/2/bb10ad74e161cdf7a2c3b27957337544en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/32104
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14216997&dopt=citationen_US
dc.description.abstractThe effect of the intraperitoneal injection of UDMH on rat tissue sulfhydryl levels, serum GOT, and urinary amino acid excretion has been studied. The approximate LD50 in rats was found to be 100 mg/kg.Rats given a single injection of 80 mg/kg of UDMH show no changes in liver or brain sulfhydryl levels, nor are serum GOT levels altered by this dose.Analyses of urine samples show that rats injected with UDMH at levels of 40, 60, or 80 mg/kg excrete correspondingly increased amounts of amino acids in the urine during the subsequent 24-hour period. It appears that this is a general increase in amino acid excretion, and abnormalities associated with specific amino acids are not apparent.Histopathologic studies do not reveal any tissue pathology as a result of this single injection of UDMH. Since neurologic symptoms are present in these animals, the present findings tend to support the evidence for a biochemical mechanism mediating the acute toxic effects of UDMH.en_US
dc.format.extent483590 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBiochemical response to 1,1-dimethylhydrazine (UDMH)en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumInstitute of Industrial Health, University of Michigan, Ann Arbor, Michigan, USA; Department of Industrial Health, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumInstitute of Industrial Health, University of Michigan, Ann Arbor, Michigan, USA; Department of Industrial Health, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.en_US
dc.identifier.pmid14216997en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/32104/1/0000154.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0041-008X(64)90088-2en_US
dc.identifier.sourceToxicology and Applied Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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