The inhibition of purine biosynthesis De novo in Bacillus subtilis by cordycepin
dc.contributor.author | Rottman, Fritz | en_US |
dc.contributor.author | Guarino, Armand J. | en_US |
dc.date.accessioned | 2006-04-13T14:47:22Z | |
dc.date.available | 2006-04-13T14:47:22Z | |
dc.date.issued | 1964-04-27 | en_US |
dc.identifier.citation | Rottman, Fritz, Guarino, Armand J. (1964/04/27)."The inhibition of purine biosynthesis De novo in Bacillus subtilis by cordycepin." Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects 80(4): 640-647. <http://hdl.handle.net/2027.42/32129> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73G7-47FWYJ9-22/2/ac507bc2a250595291451f32bffd5ad8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/32129 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14156735&dopt=citation | en_US |
dc.description.abstract | 1. 1. Cordycepin has been shown to inhibit purine biosynthesis de novo as evidenced by a decreased incorporation of radioactive formate into the nucleic acid purines of Bacillus subtilis.2. 2. The incorporation of radioactive 5-amino-4-imidazolecarboxamide into the purine ring was not severely inhibited by cordycepin.3. 3. Radiautography of an alcohol-soluble extract of B. subtilis which were grown with cordycepin and either radioactive formate or glycine failed to show an accumulation of any intermediates.4. 4. The formation of formylglycinamide ribonucleotide, which was caused to accumulate by the addition of 6-diazo-5-oxo--norleucine, was suppressed in the presence of cordycepin.These results indicate that in B. subtilis cordycepin inhibits a step in purine biosynthesis de novo which is prior to the formation of glycinamide ribonucleotide. | en_US |
dc.format.extent | 511330 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The inhibition of purine biosynthesis De novo in Bacillus subtilis by cordycepin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, Ann Arbor, Mich., U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, Ann Arbor, Mich., U.S.A. | en_US |
dc.identifier.pmid | 14156735 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/32129/1/0000182.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0926-6550(64)90308-1 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.