The kinetics of carrier-mediated transport: stationary-state approximations
dc.contributor.author | Jacquez, John A. | en_US |
dc.date.accessioned | 2006-04-13T14:47:40Z | |
dc.date.available | 2006-04-13T14:47:40Z | |
dc.date.issued | 1964-03-30 | en_US |
dc.identifier.citation | Jacquez, John A. (1964/03/30)."The kinetics of carrier-mediated transport: stationary-state approximations." Biochimica et Biophysica Acta (BBA) - Specialized Section on Biophysical Subjects 79(2): 318-328. <http://hdl.handle.net/2027.42/32136> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73G5-47G39TV-D/2/dff450f225b306b00a1b883679deb568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/32136 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14163516&dopt=citation | en_US |
dc.description.abstract | The fluxes predicted by various models of carrier-mediated active transport of amino acids have been worked out with use of the assumption of stationarity. the models considered include the various types of models in which there is a I:I carrier-amino acid binding ratio and the limiting cases of this model. The limiting case are: (I) equilibrium-reaction model: transfers of carrier and carrier-substrate complex across the cell membrane are rate limiting in comparison to the reaction between carrier and amino acid; (2) adsorption transport model: the reaction between carrier and amino acid is rate limiting. The stationary-state fluxes for an equilibrium carrier model in which carrier-amino acid stoichiometry was I:2 were also derived.The results of experiments on competition between amino acids could not be predicted by models of a I:I carrier-amino acid stoichiometry unless the assumption was also made that exchange reactions between free and carrier-bound amino acids could occur at the surfaces of the cell membrane. These exchange reactions proceed without prior dissociation of carrier-substrate complex. A model I:2 carrier-amino acid stoichiometry predicts the results of competition experiments without the necessity of assuming the existance of exchange reactions. | en_US |
dc.format.extent | 537221 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The kinetics of carrier-mediated transport: stationary-state approximations | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, Medical School, and Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Mich., U.S.A. | en_US |
dc.identifier.pmid | 14163516 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/32136/1/0000189.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0926-6577(64)90012-9 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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