Glutamine synthetase : IV. Its formation in rat liver following partial hepatectomy and during repletion
dc.contributor.author | Wu, Chung | en_US |
dc.date.accessioned | 2006-04-13T14:49:01Z | |
dc.date.available | 2006-04-13T14:49:01Z | |
dc.date.issued | 1964 | en_US |
dc.identifier.citation | Wu, Chung (1964)."Glutamine synthetase : IV. Its formation in rat liver following partial hepatectomy and during repletion." Archives of Biochemistry and Biophysics 106(): 402-409. <http://hdl.handle.net/2027.42/32167> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WB5-4DXBJSC-11B/2/64e246bc66f635fbf8b85fd0323ee662 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/32167 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14217187&dopt=citation | en_US |
dc.description.abstract | The change in glutamine synthetase activity has been studied under two conditions of liver growth, namely, mitotic growth after partial hepatectomy and nonmitotic growth during repletion after a fast. The surgical operation caused the enzyme activity in the liver to diminish to one half its normal value within one week after the operation and to remain at this reduced level for the duration of the experiment lasting 90 days. A second partial hepatectomy lowered the synthetase activity still further. The lowering appeared to have resulted from an impairment in the synthesis of the enzyme, which was associated with the high mitotic activity of the liver, and presumably with the de novo synthesis of deoxyribonucleic acid. Furthermore, partial hepatectomy did not affect the kidney enzyme, nor did unilateral nephrectomy decrease the liver enzyme.A temporary fall in the liver synthetase activity resulted from repleting after a fast; the fall depended on the diet of repletion, being greater on a low protein diet than on a high protein diet. Conversely, the kidney enzyme of the rat during repletion rose to a higher level on a low protein diet than on a high protein diet.Raising the glutamine content in the diet did not reduce the synthetase activity in rat liver, nor did omitting glutamine from the diet increase the enzyme activity. A protein-free diet, however, proved to be more detrimental to the enzyme in liver than fasting, which brought varied effects on the enzyme depending on its duration. | en_US |
dc.format.extent | 760754 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Glutamine synthetase : IV. Its formation in rat liver following partial hepatectomy and during repletion | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 14217187 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/32167/1/0000222.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0003-9861(64)90207-3 | en_US |
dc.identifier.source | Archives of Biochemistry and Biophysics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.