Ionic transfer in cardiac muscle. An explanation of cardiac electrical activity
dc.contributor.author | Reynolds, Jr. , Ernest W. | en_US |
dc.date.accessioned | 2006-04-13T14:49:11Z | |
dc.date.available | 2006-04-13T14:49:11Z | |
dc.date.issued | 1964-05 | en_US |
dc.identifier.citation | Reynolds, Jr., Ernest W. (1964/05)."Ionic transfer in cardiac muscle. An explanation of cardiac electrical activity." American Heart Journal 67(5): 693-700. <http://hdl.handle.net/2027.42/32171> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6W9H-4CN4JVJ-S5/2/5df48bac192732d559cd1fcae2fb4091 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/32171 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14156017&dopt=citation | en_US |
dc.description.abstract | The evidence has been reviewed which suggests that the upstroke of the action potential in heart muscle is due to the entry of sodium ions. This conclusion is based on the failure of the upstroke to occur if 90 per cent of the sodium is replaced by sucrose, and the demonstration of a reduction in amplitude of the rising phase of the action potential with each decrement in extracellular sodium concentration or an increase in amplitude with increasing extracellular sodium concentration. In addition, the demonstration of a change in membrane resistance of one-hundred-fold at the time of the rising phase suggests increased permeability of the membrane at this time.The voltage-clamp studies in the squid giant axon clearly show an inward movement of current during the rising phase, which disappears when choline replaces sodium in the perfusing bath.The resting membrane potential resembles the model of a potassium and chloride concentration cell, since calculations based on measured concentrations across the membrane agree fairly closely with measured potentials. Furthermore, the membrane resting potential is altered in a predictable manner by changed extracellular potassium and chloride concentration, but is not appreciably affected by changing sodium concentration. Since the skeletal muscle membrane appears to be freely permeable to chloride, and only sparingly so to potassium, and since potassium permeability is selectively altered during the electrical cycle, the chloride ionic concentration gradient is probably dependent on the transmembrane potential, and, therefore, is passive. The current carried by the chloride ion in cardiac fibers is small.Little is known of the factors which alter membrane permeability or affect the transfer rates during recovery, but it is apparent that sodium is removed from the cell after the rising phase and is replaced by potassium to restore membrane resting potential. | en_US |
dc.format.extent | 768155 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Ionic transfer in cardiac muscle. An explanation of cardiac electrical activity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.identifier.pmid | 14156017 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/32171/1/0000226.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-8703(64)90342-4 | en_US |
dc.identifier.source | American Heart Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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