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Effects of chlorpromazine on some motor reflexes,

dc.contributor.authorHudson, Roy D.en_US
dc.contributor.authorDomino, Edward F.en_US
dc.date.accessioned2006-04-13T14:50:29Z
dc.date.available2006-04-13T14:50:29Z
dc.date.issued1963-08en_US
dc.identifier.citationHudson, Roy D., Domino, Edward F. (1963/08)."Effects of chlorpromazine on some motor reflexes,." Neuropharmacology 2(3-4): 143-162. <http://hdl.handle.net/2027.42/32201>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0C-47RT3Y3-3K/2/83c02cbd5fbbf3fb48f843a99cda9335en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/32201
dc.description.abstractThe effects of chlorpromazine (CPZ) on the patellar reflex and segmentally evoked spinal cord potentials were determined in various cat preparations. CPZ in doses of 1-8 mg/kg given intravenously (as an accumulative dose) produced a significant depression of the patellar reflex and segmentally evoked potentials in animals with an intact central nervous system. Hypotension, potentiation of anesthesia, depression of nerve conduction in afferent and efferent nerves, an effect at the neuromuscular junction, or an effect directly on skeletal muscle or muscle spindle were ruled out as possible mechanisms of reflex depression.Studies in high spinal and decerebrate animals (Sherrington, Pollock-Davis) and decerebellate suggested a supraspinal sight of CPZ action. CPZ was shown to cause a significant depression of facilitation and inhibition of the patellar reflex produced by electrical stimulation of the mesencephalic facilitatory and medullary inhibitory areas of the reticular formation. The linguomandibular reflex (LMR) was also elicited in several preparations. This reflex was significantly depressed in intact and high spinal animals while the patellar reflex was depressed only in the former. CPZ-induced depression of segmentally evoked potentials was demonstrated to be dependent upon the intensity of electrical stimulation. CPZ was much less effective in depressing potentials elicited by supramaximal than by submaximal stimuli (80 per cent of maximum). The mean arterial blood pressure was depressed by CPZ in all preparations with an intact medullary vasomotor outflow.The site of CPZ depression of these motor reflexes is probably on neurons in portions of the bulbar facilitatory (BF) reticular area as well as a lesser depression of neurons in portions of the bulbar inhibitory reticular area. The possibility that CPZ may also act at a spinal level is discussed.en_US
dc.format.extent1339782 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleEffects of chlorpromazine on some motor reflexes,en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan, Ann Arbor, Michigan, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/32201/1/0000260.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0028-3908(63)90017-0en_US
dc.identifier.sourceNeuropharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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