Species differences in the eeg response to epinephrine, 5-hydroxytryptamine and nicotine in brainstem transected animals,

Abstract

Species differences have been observed in the EEG activation response to intravenous epinephrine, 5-hydroxytryptamine, and nicotine in rabbits, cats, dogs and monkeys. It was also found that a relatively high level of brainstem transection was required to induce a slow wave EEG pattern in the monkey. In midpontine** rabbits, cats and dogs and high pontine monkeys EEG activation was seen after 10-20 [mu]g/kg of nicotine. Similar doses of nicotine also produced EEG activation in prepontine S rabbits and cats but not in the prepontine dog. Also, whereas 4-8 [mu]g/kg of epinephrine and 30 [mu]g/kg 5-hydroxytryptamine produced EEG activation in the midpontine rabbit and cat, no such response was observed following the administration of these agents in the midpontine dog or high pontine monkey.