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The effect of triethyltin on mitochondrial swelling

dc.contributor.authorMoore, K. E.en_US
dc.contributor.authorBrody, Theodore M.en_US
dc.date.accessioned2006-04-13T14:57:44Z
dc.date.available2006-04-13T14:57:44Z
dc.date.issued1961-05en_US
dc.identifier.citationMoore, K. E., Brody, T. M. (1961/05)."The effect of triethyltin on mitochondrial swelling." Biochemical Pharmacology 6(3): 134-142. <http://hdl.handle.net/2027.42/32366>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4P-478FFD0-1S/2/18fe3da40f5125ce68368d6ab4b6264een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/32366
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=13772322&dopt=citationen_US
dc.description.abstractTriethyltin induces swelling of isolated rat liver mitochondria suspended in sucrose or KCl media. This effect is not seen with brain mitochondria. Triethyltin swelling is only minimally reduced by EDTA or amytal but is prevented by 2:4-dinitrophenol, cyanide or salicylate. The addition of adenosine tri- or diphosphate causes reversal of the swelling; this effect is potentiated by Mn2+ but not by Mg2+. The reversal of thyroxine-induced swelling by ATP is blocked by triethyltin, perhaps via an inhibition of the hydrolysis of adenosine triphosphate. The relationship between in vitro effects of triethyltin on mitochondria and the toxic actions of the drug in the whole animal are discussed.en_US
dc.format.extent831625 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe effect of triethyltin on mitochondrial swellingen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid13772322en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/32366/1/0000441.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-2952(61)90157-5en_US
dc.identifier.sourceBiochemical Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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