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Studies on malarial sporozoites. I. Effect of various environmental conditions

dc.contributor.authorPorter, Richard J.en_US
dc.contributor.authorLaird, Raymond L.en_US
dc.contributor.authorDusseau, Elizabeth M.en_US
dc.date.accessioned2006-04-13T15:05:23Z
dc.date.available2006-04-13T15:05:23Z
dc.date.issued1952-06en_US
dc.identifier.citationPorter, Richard J., Laird, Raymond L., Dusseau, Elizabeth M. (1952/06)."Studies on malarial sporozoites. I. Effect of various environmental conditions." Experimental Parasitology 1(3): 229-244. <http://hdl.handle.net/2027.42/32540>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WFH-4C8H7VW-T/2/b4f0abccc62ceb91eeca7e19906b9183en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/32540
dc.description.abstractData are presented on the infectivity of sporozoites of P. gallinaceum under various conditions. Mosquitoes exposed to ether in excess or to temperatures below freezing showed drastic reduction of infectivity. Considerable exposure to tobacco smoke, DDT or pyrethrum, minimal exposure to ether, or chilling at temperatures above freezing were apparently harmless to sporozoites.Saline solutions of 0.21, 0.43 and 0.85% were injurious to sporozoites. In the presence of 4.5% blood 0.85% saline was less deleterious than more or less concentrated saline solutions. Heparinized chick blood, plasma, or serum inactivated at 56 [deg]C for 30 minutes were good media, allowing prolonged survival of sporozoites. Normal serum slightly but definitely reduced infectivity. Temperatures up to 21 [deg]C allowed nearly quantitative survival of sporozoites for 3-4 hours. Temperatures of 26 [deg]C or higher markedly reduced infectivity within this period.Intravenous inoculation of sporozoites gave regular, intense infections. Intrahepatic injection was apparently nearly as good. Intramuscular, subcutaneous, and intraperitoneal inoculations resulted in irregular infections of mostly prolonged incubation period. Inoculations by stomach tube were negative. One of four orally inoculated chicks became infected with a prolonged prepatent period.A convenient method is described for routine quantitative induction of infection with sporozoites of Plasmodium gallinaceum.en_US
dc.format.extent881704 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleStudies on malarial sporozoites. I. Effect of various environmental conditionsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Tropical Diseases, School of Public Health, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Tropical Diseases, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA; Division of Preventive Medicine, University of Tennessee College of Medicine, Memphis, Tenn., USAen_US
dc.contributor.affiliationumDepartment of Tropical Diseases, School of Public Health, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/32540/1/0000651.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0014-4894(52)90013-1en_US
dc.identifier.sourceExperimental Parasitologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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