Pregnenolone and pregnenolone sulfate metabolism by human fetal testes in vitro
dc.contributor.author | Lamont, Kenneth G. | en_US |
dc.contributor.author | Perez-Palacios, Gregorio | en_US |
dc.contributor.author | Perez, Ana E. | en_US |
dc.contributor.author | Jaffe, Robert B. | en_US |
dc.date.accessioned | 2006-04-17T15:09:30Z | |
dc.date.available | 2006-04-17T15:09:30Z | |
dc.date.issued | 1970 | en_US |
dc.identifier.citation | Lamont, Kenneth G., Perez-Palacios, Gregorio, Perez, Ana E., Jaffe, Robert B. (1970)."Pregnenolone and pregnenolone sulfate metabolism by human fetal testes in vitro." Steroids 16(): 127-140. <http://hdl.handle.net/2027.42/32735> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TC9-4FW1F9K-W/2/c1a00ace24c571d75932e96928e9ded4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/32735 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4248592&dopt=citation | en_US |
dc.description.abstract | Homogenates of testes from human fetuses of 12-16 weeks gestation were incubated in vitro with pregnenolone-4-14C and pregnenolone-7-3H-sulfate. Dehydroepiandrosterone sulfate and pregnenediol sulfate, each bearing the tritium label only, were identified in the conjugated fraction. Progesterone, 17[alpha]-hydroxyprogesterone, 17[alpha]-hydroxypregnenolone, dehydroepiandrosterone, androstenedione and testosterone, each bearing both a tritium and 14C-label, were identified in the organic fraction. In a similar incubation, with pregnenolone-7-3H-sulfate-35S as substrate, the direct conversion to 17[alpha]-hydroxypregnenolone sulfate was demonstrated. The presence of slight sulfatase activity was also noted. The direct metabolism of steroid sulfates and the presence of sulfatase activity in this fetal tissue and the possible significance of these findings in the developing male fetus are discussed. | en_US |
dc.format.extent | 511071 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Pregnenolone and pregnenolone sulfate metabolism by human fetal testes in vitro | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Steroid Research Unit, Reproductive Endocrinology Program, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104, USA | en_US |
dc.contributor.affiliationum | Steroid Research Unit, Reproductive Endocrinology Program, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104, USA | en_US |
dc.contributor.affiliationum | Steroid Research Unit, Reproductive Endocrinology Program, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104, USA | en_US |
dc.contributor.affiliationum | Steroid Research Unit, Reproductive Endocrinology Program, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104, USA | en_US |
dc.identifier.pmid | 4248592 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/32735/1/0000104.pdf | en_US |
dc.identifier.source | Steroids | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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