Testosterone metabolism in target tissues: Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis
dc.contributor.author | Jaffe, Robert B. | en_US |
dc.date.accessioned | 2006-04-17T15:15:44Z | |
dc.date.available | 2006-04-17T15:15:44Z | |
dc.date.issued | 1969-11 | en_US |
dc.identifier.citation | Jaffe, Robert B. (1969/11)."Testosterone metabolism in target tissues: Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis." Steroids 14(5): 483-498. <http://hdl.handle.net/2027.42/32875> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TC9-4FN70P7-4/2/c2abda20375f88c5db63e71f62d157c8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/32875 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5356910&dopt=citation | en_US |
dc.description.abstract | Rat pituitary, hypothalamic and cerebral cortical minces are demonstrated to effect the conversion of testosterone (T) to 5[alpha]-androstan-17[beta]-o1-3-one (DHT) and [Delta]4-androstene-3,17-dione ([Delta]4A). The pituitary effected the greatest conversion of T to both DHT and [Delta]4A. The hypothalamus converted more T to DHT than did the cerebral cortex; but the conversion of T to [Delta]4A in these two tissues occured to approximately the same extent. Analysis of the time course of the conversion of T to DHT in these tissues demonstrated the conversion to increase in a linear fashion over 180 min., while the maximum conversions in the hypothalamus and cerebral cortex were reached by 120 min.The conversion of T to DHT and [Delta]4A was also demonstrated in the human fetal hypothalamus and pituitary, and in the distal femoral epiphysis of the growing rat. In the femoral epiphysis, 5[alpha]-androstane-3[alpha],17[beta]-diol was also identified. | en_US |
dc.format.extent | 539978 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Testosterone metabolism in target tissues: Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Steroid Research Unit, Reproductive Endocrinology Program, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48104, USA | en_US |
dc.identifier.pmid | 5356910 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/32875/1/0000253.pdf | en_US |
dc.identifier.source | Steroids | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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