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Lipoatrophic diabetes: An improved procedure for the isolation and purification of a diabetogenic polypeptide from urine
dc.contributor.authorLouis, Lawrence H.en_US
dc.date.accessioned2006-04-17T15:18:50Z
dc.date.available2006-04-17T15:18:50Z
dc.date.issued1969-07en_US
dc.identifier.citationLouis, Lawrence H. (1969/07)."Lipoatrophic diabetes: An improved procedure for the isolation and purification of a diabetogenic polypeptide from urine." Metabolism 18(7): 545-555. <http://hdl.handle.net/2027.42/32943>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WN4-4C4WC9R-B2/2/1ed06a3c985ec3699102f0942b1cd0d4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/32943
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5788258&dopt=citationen_US
dc.description.abstractAn improved procedure is outlined for the isolation of a diabetogenic polypeptide from urine of patients with lipoatrophic diabetes. The compound provokes insulin resistance and temporary loss of glucose tolerance when administered to dogs and humans. It is now free of a toxic contaminant which, by the previous method, had to be removed by more drastic treatment of the compound than was deemed suitable. Its physicochemical properties closely resemble those of a diabetogenic polypeptide isolated from the adenohypophyses of beef, sheep, and hog described previously from this laboratory.en_US
dc.format.extent497160 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleLipoatrophic diabetes: An improved procedure for the isolation and purification of a diabetogenic polypeptide from urineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMetabolism Research Unit, University of Michigan Medical School, Ann Arbor, Mich, USA; Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan Medical School, Ann Arbor, Mich, USA.en_US
dc.identifier.pmid5788258en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/32943/1/0000326.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0026-0495(69)90088-2en_US
dc.identifier.sourceMetabolismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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