The effect of sympatholytic agents on the cardiovascular responses produced by the injection of acetylstrophanthidin into the cerebral ventricles

Abstract

The administration of acetylstrophanthidin into the left lateral ventricle of dogs anesthetized with alpha-chloralose produces ventricular arrhythmias and a marked pressor response. The pressorr response is not prevented by the intravenous or intraventricular administration of d,l-propranolol nor by reserpine-pretreatment. However, the centrally-induced pressor response is reversed by intravenously administered d,l-propranolol but not by d-propranolol. The mechanism by which d,l-propranolol exerts this effect is discussed. The ventricular arrhythmias did not occur after reserpine-pretreatment or after the intraventricular injection of d,l-propranolol. The arrhythmias were affected by neither the intravenous administration of d,l-propranolol nor the intraventricular injection of d-propranolol.