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Differential effects of pentobarbital, ethyl alcohol, and chlorpromazine in modifying reticular facilitation of visually evoked responses in the cat

dc.contributor.authorYoshihisa Nakai,en_US
dc.contributor.authorDomino, Howard F.en_US
dc.date.accessioned2006-04-17T15:23:33Z
dc.date.available2006-04-17T15:23:33Z
dc.date.issued1969-01en_US
dc.identifier.citationYoshihisa Nakai, , Domino, Howard F. (1969/01)."Differential effects of pentobarbital, ethyl alcohol, and chlorpromazine in modifying reticular facilitation of visually evoked responses in the cat." Neuropharmacology 8(1): 61-66. <http://hdl.handle.net/2027.42/33045>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0C-478C130-17/2/f50052ffdf118c273c6c5b81d754cf42en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33045
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5782999&dopt=citationen_US
dc.description.abstractCortical visually evoked responses (VER) elicited by electrical stimulation of the ipsilateral optic tract were dramatically facilitated by stimulation of the midbrain reticular formation. This facilitation depended on the experimental conditions used, such as the intensity and time course of reticular (RFs) and optic tract stimulation (OTs). Reticular facilitation of the VER was most intense at 8 times the EEG activating threshold with a 50 msec interval between the RFs and OTs. The effects of increasing accumulative doses of pentobarbital, ethyl alcohol, and chlorpromazine given i.v. on reticular facilitation of the VER were observed. In general. these agents did not alter the presynaptic component of the VER except for 32 mg/kg of pentobarbital which increased it. On the other hand, pentobarbital had a marked depressant effect on both the cortical postsynaptic components and relicular influences on them. However. pentobarbital did not depress reticular facilitation of the VER as much as the non-facilitated VER. This data would suggest that pentobarbital has a neocortical depressant effect which is somewhat greater than its effect on the midbrain reticular formation. Ethyl alcohol had a similar cortical depressant effect but produced no significant depression of reticular facilitation of the VER. In fact, RFs restored the VER almost to control. Chlorpromazine (0.5 mg/kg, i.v.) reduced slightly the cortical postsynaptic components of the VER but had no effect on its facilitation by RFs.These results suggest that reticular facilitation of the VER is more resistant to depression by pentobarbital and ethyl alcohol than the VER alone. The postsynaptic components of the VER are quite sensitive to the effects of these drugs in contrast to its presynaptic component. In marked contrast to the actions of pentobarbital and ethyl alcohol, chlorpromazine showed much less of a postsynaptic neocortical depressant effect even when massive doses (up to 16 mg/kg) were used.en_US
dc.format.extent969908 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDifferential effects of pentobarbital, ethyl alcohol, and chlorpromazine in modifying reticular facilitation of visually evoked responses in the caten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A.en_US
dc.identifier.pmid5782999en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33045/1/0000431.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0028-3908(69)90036-7en_US
dc.identifier.sourceNeuropharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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