Acute and short-term oral toxicity of 2-n-ethylaminoethanol in rats

Abstract

Acute oral doses of neutralized 2-N-ethylaminoethanol (EAE) in rats greatly increased gastric secretion, resulting in dehydration and death after 3-4 days. The effect of EAE on gastric secretion did not appear to be due to osmotic effects or to histopathological changes in the gastro-intestinal tract.Short-term administration of neutralized EAE in the drinking water produced evidence ofpronounced cumulative toxicity. The 30-day LC50 was 1412 [plus-or-minus sign] 710 ppm. At lower concentrations given over a period of 90 days the main toxic effects of EAE were retardation of growth and degenerative changes in the liver and kidneys. A concentration of 25 ppm EAE in the drinking water for 90 days resulted in minor changes and was considered to be close to the no-effect level.