Histidine transport into isolated animal cells
dc.contributor.author | Christensen, Halvor N. | en_US |
dc.date.accessioned | 2006-04-17T15:26:29Z | |
dc.date.available | 2006-04-17T15:26:29Z | |
dc.date.issued | 1968-09-03 | en_US |
dc.identifier.citation | Christensen, Halvor N. (1968/09/03)."Histidine transport into isolated animal cells." Biochimica et Biophysica Acta (BBA) - General Subjects 165(2): 251-261. <http://hdl.handle.net/2027.42/33112> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1W-47MCRSP-JW/2/f91f07f8cccaa068e625eac7b68433d8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33112 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5683525&dopt=citation | en_US |
dc.description.abstract | At pH values where it is predominantly without net charge, histidine in dilute solution divided its uptake by the Ehrlich cell between the Na+-independent L system and the Na+-requiring A system. As in every other case studied the L component was partially inhibitable by lysine, partially not. At pH 5, where it is chiefly a cation, an additional component became perceptible, one which could be inhibited by lysine but not by neutral amino acids, which is assigned to the Ly+ system.These observations extend generalizations suggesting that the L and Ly+ systems are associated so that partially competitive inhibition occurs between their respective substrates. An apparent heterogeneity in the interaction between histidine and phenylalanine in the constant-ratio test is probably explained by the role of the Ly+ system in histidine uptake expected for the cationic form of histidine even at pH 7.4. In various erythrocytes histidine uptake was simpler because of the absence of an A system and the minimal reactivity of histidine with any other Na+-requiring system. Although it reacted here also both as a cation and a neutral amino acid, interaction between the corresponding transport systems was inconspicuous. | en_US |
dc.format.extent | 657715 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Histidine transport into isolated animal cells | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, Ann Arbor, Mich., U.S.A. | en_US |
dc.identifier.pmid | 5683525 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33112/1/0000498.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-4165(68)90053-6 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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