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Protein, enzyme, and isoenzyme distribution in human serum fractions obtained by ultracentrifugation

dc.contributor.authorPruden, Elizabeth L.en_US
dc.contributor.authorCreason, Paul L.en_US
dc.contributor.authorCreason, Marilyn T.en_US
dc.contributor.authorBlock, Walter D.en_US
dc.date.accessioned2006-04-17T15:29:20Z
dc.date.available2006-04-17T15:29:20Z
dc.date.issued1968-05en_US
dc.identifier.citationPruden, Elizabeth L., Creason, Paul L., Creason, Marilyn T., Block, Walter D. (1968/05)."Protein, enzyme, and isoenzyme distribution in human serum fractions obtained by ultracentrifugation." Clinica Chimica Acta 20(2): 173-180. <http://hdl.handle.net/2027.42/33176>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T57-47PR9TF-DW/2/09f8361e6eb55da21ff266c8e501e8dcen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33176
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4172871&dopt=citationen_US
dc.description.abstractWe have described the protein, enzyme, and isoenzyme characteristics of three gross fractions of both normal and abnormal human sera, as obtained by application of high centrifugal force. In the absence of solution gradient, such fractions represent pure and undiluted elements of the serum; they are reproducible and sufficiently voluminous for extensive analytical study. Specific features of these fractions may be of interest in planning additional or peripheral investigations of serum. Fraction I appears to be a fair sample of native serum water; Fraction II appears to segregate the pre-[beta]-globulin lipoprotein component observed in some sera; Fraction III is a concentrated solution of LDH, CPK, and SGOT enzymes, and [gamma]-globulin-rich protein, which is hpoprotein-free. More than 95% of the LDH, CPK, and SGOT is located in Fractions II and III. Quantitative activity and qualitative nature of these enzymes appears to survive the stress of the ultracentrifuge technique relatively well.en_US
dc.format.extent681238 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleProtein, enzyme, and isoenzyme distribution in human serum fractions obtained by ultracentrifugationen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Dermatology, School of Medicine and Health Development, School of Public Health, University of Michigan, Ann Arbor, Mich., U.S.A.en_US
dc.contributor.affiliationotherCaylor-Nickel Research Foundation, Bluffton, Ind., U.S.A.en_US
dc.contributor.affiliationotherCaylor-Nickel Research Foundation, Bluffton, Ind., U.S.A.en_US
dc.contributor.affiliationotherCaylor-Nickel Research Foundation, Bluffton, Ind., U.S.A.en_US
dc.identifier.pmid4172871en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33176/1/0000563.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0009-8981(68)90147-2en_US
dc.identifier.sourceClinica Chimica Actaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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