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A diabetogenic polypeptide from bovine adenohypophysis similar to that excreted in lipoatrophic diabetes,
dc.contributor.authorLouis, Lawrence H.en_US
dc.contributor.authorConn, Jerome W.en_US
dc.contributor.authorMinick, Merlyn C.en_US
dc.date.accessioned2006-04-17T16:17:05Z
dc.date.available2006-04-17T16:17:05Z
dc.date.issued1966-04en_US
dc.identifier.citationLouis, Lawrence H., Conn, Jerome W., Minick, Merlyn C. (1966/04)."A diabetogenic polypeptide from bovine adenohypophysis similar to that excreted in lipoatrophic diabetes,." Metabolism 15(4): 309-324. <http://hdl.handle.net/2027.42/33461>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WN4-4C4WBJ9-1D/2/ce2d30a6324d47f5260f8f9b04275224en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33461
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4285865&dopt=citationen_US
dc.description.abstractA polypeptide has been isolated from bovine adenohypophysis which antagonizes the hypoglycemic effect of exogenous insulin and which, per se, induces loss of carbohydrate tolerance in men and dogs. Mild acid hydrolysis of the active polypeptide yields a compound which retains the same biological properties. Characteristics of the active principle and its hydrolytic product is the long duration of their activities, the greatest intensity of the effects being observed between 34 and 60 hours after a single intramuscular injection. Both substances are devoid of ACTH activity. The active polypeptide resembles closely the insulin antagonist isolated from the urine of patients with lipoatrophic diabetes previously reported from this laboratory. Details of the isolation and physiologic effects of the active substance and its hydrolytic product are described.en_US
dc.format.extent702288 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleA diabetogenic polypeptide from bovine adenohypophysis similar to that excreted in lipoatrophic diabetes,en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine (Division of Endocrinology and Metabolism and the Metabolism Research Unit), the University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine (Division of Endocrinology and Metabolism and the Metabolism Research Unit), the University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine (Division of Endocrinology and Metabolism and the Metabolism Research Unit), the University of Michigan Medical School, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid4285865en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33461/1/0000865.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0026-0495(66)90145-4en_US
dc.identifier.sourceMetabolismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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