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Hypoglycemic action of 2-aminonorbornane-2-carboxylic acid in the rat
dc.contributor.authorTager, Howard S.en_US
dc.contributor.authorChristensen, Halvor N.en_US
dc.date.accessioned2006-04-17T16:24:53Z
dc.date.available2006-04-17T16:24:53Z
dc.date.issued1971-07-02en_US
dc.identifier.citationTager, H.S., Christensen, H.N. (1971/07/02)."Hypoglycemic action of 2-aminonorbornane-2-carboxylic acid in the rat." Biochemical and Biophysical Research Communications 44(1): 185-191. <http://hdl.handle.net/2027.42/33611>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4G0VTNW-NY/2/ae914681d72fce59893eac14ff2b5953en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33611
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5116508&dopt=citationen_US
dc.description.abstractSummaryCorrect orientation of the amino and carboxyl groups and of the bicyclic ring of the compound 2-aminonorbornane-2-carboxylic acid is essential for its induction of a tolbutamide-potentiated hypolycemia in the rat, an effect which we have already shown to arise from stimulation of insulin release. Only that isomer with its carboxyl group exo and the absolute configuration 1R, 2S, 4S has this action. This finding provides a partial description of a recognition site whereby neutral amino acids stimulate insulin release.en_US
dc.format.extent312118 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleHypoglycemic action of 2-aminonorbornane-2-carboxylic acid in the raten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Ann Arbor, Michigan 48104, USAen_US
dc.identifier.pmid5116508en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33611/1/0000115.pdfen_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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