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Uptake of dihydromorphine- 3H by synaptosomes

dc.contributor.authorHug, Carl C. Jr.en_US
dc.contributor.authorOka, T.en_US
dc.date.accessioned2006-04-17T16:29:29Z
dc.date.available2006-04-17T16:29:29Z
dc.date.issued1971-02-15en_US
dc.identifier.citationHug, Jr., C. C., Oka, T. (1971/02/15)."Uptake of dihydromorphine- 3H by synaptosomes." Life Sciences 10(4, Part 1): 201-213. <http://hdl.handle.net/2027.42/33707>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-491STPK-4/2/6d39f4944a455e45814c5e4f24f192efen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33707
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4102559&dopt=citationen_US
dc.description.abstractTritium-labeled dihydromorphine (DHM-3H) was accumulated by the synaptosomal fraction (nerve endings) of rat cerebral cortex. Particles derived from nerve endings by osmotic shock exhibited a higher concentration of DHM- 3H than did other subcellular fractions of brain when the isolated fractions were incubated with the drug . Nalorphine in large concentrations reduced the uptake of DHM- 3H by all fractions to the same degree. No difference was apparent in the uptake of DHM- 3H by subcellular fractions from non-tolerant and morphine-tolerant rats. The uptake of DHM- 3H by nerve endings was attributed to a binding phenomenon, although an active transport process may provide the drug an access to the binding sites in the intact tissue.en_US
dc.format.extent597328 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleUptake of dihydromorphine- 3H by synaptosomesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48104, USAen_US
dc.identifier.pmid4102559en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33707/1/0000219.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(71)90249-9en_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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