[lambda]imm[lambda][middle dot]434: A phage with a hybrid immunity region
dc.contributor.author | Wilgus, Gerald S. | en_US |
dc.contributor.author | Mural, Richard J. | en_US |
dc.contributor.author | Friedman, David I. | en_US |
dc.contributor.author | Fiandt, Michael | en_US |
dc.contributor.author | Szybalski, Waclaw | en_US |
dc.date.accessioned | 2006-04-17T16:34:10Z | |
dc.date.available | 2006-04-17T16:34:10Z | |
dc.date.issued | 1973-11 | en_US |
dc.identifier.citation | Wilgus, Gerald S., Mural, Richard J., Friedman, David I., Fiandt, Michael, Szybalski, Waclaw (1973/11)."[lambda]imm[lambda][middle dot]434: A phage with a hybrid immunity region." Virology 56(1): 46-53. <http://hdl.handle.net/2027.42/33781> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WXR-4BNMM6T-6/2/d0e8eb9cc1d0f58f5c8a5076215758da | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33781 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4583309&dopt=citation | en_US |
dc.description.abstract | The genomes of coliphages [lambda] and [lambda]imm434 are identical with the exception of the immunity region, which codes for the respective repressors and corresponding operators. Although previous genetic studies failed to detect any recombinations that might have occurred within the immunity regions of these two phages, electron-micrographic heteroduplex mapping demonstrated a short interval of homology between [lambda] and [lambda]imm434 DNA located in this otherwise heterologous region. We report the isolation of a recombinant which resulted from a cross-over event between [lambda] and [lambda]imm434 within the immunity region. This phage, denoted [lambda]imm[lambda][middle dot]434, carries the leftward promoter-operator as well as gene rex of [lambda] and the rightward promoter-operator as well as gene tof (cro) of phage 434. Since the recombination occurred within the cI gene, phage [lambda]imm[lambda][middle dot]434 must carry a hybrid repressor gene. | en_US |
dc.format.extent | 691774 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | [lambda]imm[lambda][middle dot]434: A phage with a hybrid immunity region | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology, University of Michigan Medical School, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Microbiology, University of Michigan Medical School, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Microbiology, University of Michigan Medical School, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.contributor.affiliationother | McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, U.S.A. | en_US |
dc.contributor.affiliationother | McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, U.S.A. | en_US |
dc.identifier.pmid | 4583309 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33781/1/0000035.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0042-6822(73)90286-9 | en_US |
dc.identifier.source | Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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