The oxidation of choline by liver slices and mitochondria during liver development in the rat
dc.contributor.author | Weinhold, Paul A. | en_US |
dc.contributor.author | Sanders, Robert D. | en_US |
dc.date.accessioned | 2006-04-17T16:36:41Z | |
dc.date.available | 2006-04-17T16:36:41Z | |
dc.date.issued | 1973-09-01 | en_US |
dc.identifier.citation | Weinhold, Paul A., Sanders, Robert (1973/09/01)."The oxidation of choline by liver slices and mitochondria during liver development in the rat." Life Sciences 13(5): 621-629. <http://hdl.handle.net/2027.42/33824> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-474Y977-JS/2/8c83e6ac9ccfb45f7522c782c1a0fcee | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33824 | |
dc.description.abstract | Betaine is the major oxidation product of [Me-14C] choline produced by rat liver slices. Liver slices from adult rats rapidly oxidize [Me-14C] choline to betaine and the bulk of the betaine produced is recovered in the incubation medium. Considerably more choline is oxidized to betaine than is phosphorylated to phosphorylcholine. The rate of phosphorylation of choline appears to be independent of the rate of choline oxidation. Liver slices from fetal and young rats oxidize choline to betaine at a lower rate than adult liver slices.The ability of mitochondria to oxidize [Me-14C] choline to betaine aldehyde and betaine is considerably lower in fetal liver than in adult liver. The major product with both fetal and adult mitochondria is betaine aldehyde. Choline oxidation by mitochondria begins to increase 1 day prior to birth and increases progressively to adult levels by 18 days. The developmental pattern for choline oxidation is similar to the pattern for succinic dehydrogenase activity. | en_US |
dc.format.extent | 320395 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The oxidation of choline by liver slices and mitochondria during liver development in the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Veterans Administration Hospital and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48105, USA | en_US |
dc.contributor.affiliationum | Veterans Administration Hospital and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48105, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33824/1/0000081.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(73)90055-6 | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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