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Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement

dc.contributor.authorDomino, Edward F.en_US
dc.contributor.authorLutz, Michael P.en_US
dc.date.accessioned2006-04-17T16:37:57Z
dc.date.available2006-04-17T16:37:57Z
dc.date.issued1973en_US
dc.identifier.citationDomino, Edward F., Lutz, Michael P. (1973)."Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement." Pharmacology Biochemistry and Behavior 1(4): 445-448. <http://hdl.handle.net/2027.42/33852>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0N-478G1B2-C/2/df2cdb32a9aa0d6393112ed940196e52en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33852
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4777580&dopt=citationen_US
dc.description.abstractThe effects of daily nicotine tartrate given IP in a dose of 0.25 mg/kg twice a day for 15 days was studied on bar pressing behavior for water reinforcement in the rat. A modified FR1 5 schedule was used. Nicotine injections caused an initial disruption of bar pressing behavior with rapid tolerance development. Antidiuretic hormone (5-10 units/kg, SC) administration also suppressed water drinking behavior after an initial latency in contrast to the effects of nicotine. It is concluded that tolerance occurs to daily nicotine administration.en_US
dc.format.extent254661 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleTolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcementen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.identifier.pmid4777580en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33852/1/0000111.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0091-3057(73)90011-7en_US
dc.identifier.sourcePharmacology Biochemistry and Behavioren_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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