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Acetylcholine stimulates hydrolysis of 32P-labeled phosphatidic acid in guinea pig synaptosomes
dc.contributor.authorSchacht, Jochenen_US
dc.contributor.authorAgranoff, Bernard W.en_US
dc.date.accessioned2006-04-17T16:42:16Z
dc.date.available2006-04-17T16:42:16Z
dc.date.issued1973-02-05en_US
dc.identifier.citationSchacht, Jochen, Agranoff, Bernard W. (1973/02/05)."Acetylcholine stimulates hydrolysis of 32P-labeled phosphatidic acid in guinea pig synaptosomes." Biochemical and Biophysical Research Communications 50(3): 934-941. <http://hdl.handle.net/2027.42/33946>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DXKBG4-13C/2/1879c3451359ad6e744a82457b477406en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33946
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4347533&dopt=citationen_US
dc.description.abstract[3H]-inositol or [3H]-arachidonate was injected intracerebrally into guinea pigs. Labeled nerve endings were incubated with Ach* or CCh, both of which stimulate labeling of PhA and PhI from 32Pi by &gt; 100% and 70% respectively. Their addition did not affect the labeled phosphatidyl-[3H]-inositol or [3H]-arachidonyl-diglyceride and -PhI. Enhanced hydrolysis of [3H]-inositol-PhiP and -PhIP2 in the presence of ACh, CCh or choline was not reversed by atropine. In a two-step experiment, PhA was labeled with 32Pi, and DNP was added to block further [gamma]-[32P]-ATP formation. Addition of ACh stimulated an atropine-sensitive in [32P]-PhA.en_US
dc.format.extent432238 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAcetylcholine stimulates hydrolysis of 32P-labeled phosphatidic acid in guinea pig synaptosomesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48104, USA; Neuroscience Laboratory, Mental Health Research Institute University of Michigan, Ann Arbor, Michigan 48104, USA.en_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48104, USA; Neuroscience Laboratory, Mental Health Research Institute University of Michigan, Ann Arbor, Michigan 48104, USA.en_US
dc.identifier.pmid4347533en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33946/1/0000213.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(73)91335-1en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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