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The effect of daily ingestion of caffeine on the microsomal enzymes of rat liver
dc.contributor.authorKhanna, K. L.en_US
dc.contributor.authorCornish, Herbert H.en_US
dc.date.accessioned2006-04-17T16:42:19Z
dc.date.available2006-04-17T16:42:19Z
dc.date.issued1973-02en_US
dc.identifier.citationKhanna, K. L., Cornish, H. H. (1973/02)."The effect of daily ingestion of caffeine on the microsomal enzymes of rat liver." Food and Cosmetics Toxicology 11(1): 11-17. <http://hdl.handle.net/2027.42/33947>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B73F7-479CBGD-3/2/f104cb6a157a3dbfc33c1bdde5010c73en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/33947
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4716126&dopt=citationen_US
dc.description.abstractThe effect of repeated ingestion of caffeine on rat-liver microsoma enzymes was studied. In the rat, ingestion of 20-24 mg caffeine/kg/day in the drinking water for more than 2 wk inhibited aminopyrine N-demethylase activity. This loss of activity approached 60% at the end of an 8-wk dosing schedule. Acetanilide-hydroxylating activity of the rat-liver microsomal enzyme was initially stimulated, with a peak (145 +/- 11% of control) at 2 wk, and returned to normal levels at the end of 8 wk. Caffeine-treated rats did not respond to the phenobarbitone stimulation of microsomal enzymes to the same extent as did rats treated with phenobarbitone alone.en_US
dc.format.extent452161 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe effect of daily ingestion of caffeine on the microsomal enzymes of rat liveren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationumDepartment of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.identifier.pmid4716126en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/33947/1/0000216.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0015-6264(73)90057-6en_US
dc.identifier.sourceFood and Cosmetics Toxicologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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