Effects of physostigmine on brain acetylcholine content and release
dc.contributor.author | Bartolini, A. | en_US |
dc.contributor.author | Bartolini, Rosalia | en_US |
dc.contributor.author | Domino, Edward F. | en_US |
dc.date.accessioned | 2006-04-17T16:43:11Z | |
dc.date.available | 2006-04-17T16:43:11Z | |
dc.date.issued | 1973-01 | en_US |
dc.identifier.citation | Bartolini, A., Bartolini, Rosalia, Domino, E. F. (1973/01)."Effects of physostigmine on brain acetylcholine content and release,." Neuropharmacology 12(1): 15-25. <http://hdl.handle.net/2027.42/33966> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0C-475BDK2-9G/2/117656c6aeee0b717316a3df31531f17 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/33966 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4687272&dopt=citation | en_US |
dc.description.abstract | The content and release of acetylcholine (ACh) from cat brain and ACh content of rat brain was measured using the frog rectus and leech muscle bioassays before and after physostigmine 100 [mu]g/kgi.v. or i.p. The drug elevates steady state levels of brain ACh of awake animals especially in the neocortex, caudate nucleus and hippocampus but much less so in the lateral geniculate and superior colliculus. Physostigmine was shown to produce neocortical release of ACh through a subcortical mechanism in brainstem transected cats and to decrease ACh neocortical content in pentobarbital anesthetized cats and rats. The neocortical release of ACh seems to be mediated primarily through a subcortical brain mechanism which is activated by physostigmine. It is postulated that the ascending reticular formation is involved. Local application of scopolamine (1 [mu]g/ml) into the collecting cup did not antagonize the effects of 100 [mu]g/kg of physostigmine i.v. as much as l mg/kg of scopolamine i.v. On the other hand, 2 mg/kg of mecamylamine given i.v. not only did not antagonize physostigmine-induced neocortical release of ACh, but seemed to enhance it. The results indicate a complex action of physostigmine on the cholinergic system of the brain. | en_US |
dc.format.extent | 874723 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of physostigmine on brain acetylcholine content and release | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.identifier.pmid | 4687272 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/33966/1/0000237.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0028-3908(73)90127-5 | en_US |
dc.identifier.source | Neuropharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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