Synthetic inhibitors of galactocerebroside biosynthesis
dc.contributor.author | Arora, Ramesh C. | en_US |
dc.contributor.author | Radix, Norman S. | en_US |
dc.date.accessioned | 2006-04-17T16:48:35Z | |
dc.date.available | 2006-04-17T16:48:35Z | |
dc.date.issued | 1972-06-19 | en_US |
dc.identifier.citation | Arora, Ramesh C., Radix, Norman S. (1972/06/19)."Synthetic inhibitors of galactocerebroside biosynthesis." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 270(2): 254-259. <http://hdl.handle.net/2027.42/34083> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1X-47FX9NN-P9/2/d688d1fe0c5cfbb71381021e03bfae61 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34083 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5041429&dopt=citation | en_US |
dc.description.abstract | 1. 1. The brain enzyme which forms galactosyl ceramide ("cerebroside") from UDPGal and hydroxy ceramide was assayed in vitro with a rat brain preparation. Various synthetic substances resembling hydroxy ceramide were tested as possible inhibitors. Strong inhibition was obtained with . The degree of inhibition was found to he independent of length of incubation, and kinetic analysis indicated that the amide acted as a noncompetitive inhibitor with respect to either substrate.2. 2. Deletion of either one of the two hydroxyl groups in the amide weakened the inhibitory effect, as did replacement of the bromine atom by hydrogen, chlorine, or iodine. | en_US |
dc.format.extent | 408219 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Synthetic inhibitors of galactocerebroside biosynthesis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, Mich 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, Mich 48104, U.S.A. | en_US |
dc.identifier.pmid | 5041429 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34083/1/0000362.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0005-2760(72)90237-8 | en_US |
dc.identifier.source | Biochimica et Biophysica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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