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Synthetic inhibitors of galactocerebroside biosynthesis

dc.contributor.authorArora, Ramesh C.en_US
dc.contributor.authorRadix, Norman S.en_US
dc.date.accessioned2006-04-17T16:48:35Z
dc.date.available2006-04-17T16:48:35Z
dc.date.issued1972-06-19en_US
dc.identifier.citationArora, Ramesh C., Radix, Norman S. (1972/06/19)."Synthetic inhibitors of galactocerebroside biosynthesis." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 270(2): 254-259. <http://hdl.handle.net/2027.42/34083>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T1X-47FX9NN-P9/2/d688d1fe0c5cfbb71381021e03bfae61en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/34083
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5041429&dopt=citationen_US
dc.description.abstract1. 1. The brain enzyme which forms galactosyl ceramide ("cerebroside") from UDPGal and hydroxy ceramide was assayed in vitro with a rat brain preparation. Various synthetic substances resembling hydroxy ceramide were tested as possible inhibitors. Strong inhibition was obtained with . The degree of inhibition was found to he independent of length of incubation, and kinetic analysis indicated that the amide acted as a noncompetitive inhibitor with respect to either substrate.2. 2. Deletion of either one of the two hydroxyl groups in the amide weakened the inhibitory effect, as did replacement of the bromine atom by hydrogen, chlorine, or iodine.en_US
dc.format.extent408219 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSynthetic inhibitors of galactocerebroside biosynthesisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Mich 48104, U.S.A.en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Mich 48104, U.S.A.en_US
dc.identifier.pmid5041429en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/34083/1/0000362.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0005-2760(72)90237-8en_US
dc.identifier.sourceBiochimica et Biophysica Actaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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