Depressed RNA synthesis in the brains and livers of thyroidectomized, normal and hormone injected rats
dc.contributor.author | Kohl, Herbert H. | en_US |
dc.date.accessioned | 2006-04-17T16:49:24Z | |
dc.date.available | 2006-04-17T16:49:24Z | |
dc.date.issued | 1972-05-26 | en_US |
dc.identifier.citation | Kohl, Herbert H. (1972/05/26)."Depressed RNA synthesis in the brains and livers of thyroidectomized, normal and hormone injected rats." Brain Research 40(2): 445-458. <http://hdl.handle.net/2027.42/34101> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4835W99-G0/2/41de1e9f087499632b6b7b0a3e92afaf | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34101 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5027171&dopt=citation | en_US |
dc.description.abstract | Depression of rat brain and liver RNA synthesis was seen at 22 and 90 days subsequent to neonatal radiothyroidectomy. Cerebral RNA synthesis (per unit DNA) was depressed by 16% (P P in vitro assay systems which circumvented complications (often seen in vivo approaches) such as pool size changes, cell membrane transport alterations and mediation of blood-brain barrier related effects.Chronic daily administration in vivo of -thyroxine (10 [mu]g/100 g body weight) restored the depressed cerebral synthesis of RNA to normal levels while daily administration of bovine growth hormone (100 [mu]g per rat) did not. | en_US |
dc.format.extent | 727076 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Depressed RNA synthesis in the brains and livers of thyroidectomized, normal and hormone injected rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Mich. 48104, U.S.A. | en_US |
dc.identifier.pmid | 5027171 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34101/1/0000383.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(72)90145-X | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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