The positive inotropic action of insulin in the canine heart
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.contributor.author | Medina, Marcelo | en_US |
dc.contributor.author | Kniffen, Frank J. | en_US |
dc.date.accessioned | 2006-04-17T16:50:22Z | |
dc.date.available | 2006-04-17T16:50:22Z | |
dc.date.issued | 1972-04 | en_US |
dc.identifier.citation | Lucchesi, Benedict R., Medina, Marcelo, Kniffen, Frank J. (1972/04)."The positive inotropic action of insulin in the canine heart." European Journal of Pharmacology 18(1): 107-115. <http://hdl.handle.net/2027.42/34122> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1J-479DTDS-2S/2/95804916b551799e6a3a8f290bc469db | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34122 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5031268&dopt=citation | en_US |
dc.description.abstract | The effects of glucagon-low insulin were studied on canine isolated papillary muscles incubated in Chenoweth-Kolle solution and in the pentobarbital anesthetized dog. Insulin, 12.5 mU/ml, increased developed isometric tension of papillary muscles which had equilibrated for 17 hrs, but not in muscles incubated up to 60 min. The decrease in isometric tension produced by propranolol, 10-6 M, but not that due to pentobarbital sodium, 80 [mu]g/ml, was reversed by insulin. The positive inotropic effect of insulin was obtained when pyruvate, fumarate and glutamate replaced glucose as substrate in the Chenoweth-Kolle solution. The intracoronary administration of insulin, 0.1 U/kg, increased left ventricular isometric tension and the rate of tension development in dog hearts depressed with propranolol, 2 mg/kg. Insulin exerts a direct positive inotropic effect upon canine heart muscle depressed by propranolol or due to prolonged incubation. The effect is not dependent upon catecholamines, glucagon or glucose. The positive inotropic effect is not observed in non-depressed hearts or in barbiturate depressed hearts. | en_US |
dc.format.extent | 567553 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The positive inotropic action of insulin in the canine heart | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Medical School, Department of Pharmacology, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.contributor.affiliationum | University of Michigan, Medical School, Department of Pharmacology, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.contributor.affiliationum | University of Michigan, Medical School, Department of Pharmacology, Ann Arbor, Michigan 48104, U.S.A. | en_US |
dc.identifier.pmid | 5031268 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34122/1/0000406.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-2999(72)90137-9 | en_US |
dc.identifier.source | European Journal of Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.