Systems approach to the study of drug transport across membranes using suspension cultures of mammalian cells : I. Theoretical diffusion models
dc.contributor.author | Ho, Norman F. H. | en_US |
dc.contributor.author | Turi, J. | en_US |
dc.contributor.author | Shipman, Charles Jr. | en_US |
dc.contributor.author | Higuchi, William I. | en_US |
dc.date.accessioned | 2006-04-17T16:51:42Z | |
dc.date.available | 2006-04-17T16:51:42Z | |
dc.date.issued | 1972-03 | en_US |
dc.identifier.citation | Ho, N. F. H., Turi, J., Shipman, Jr, C., Higuchi, W. I. (1972/03)."Systems approach to the study of drug transport across membranes using suspension cultures of mammalian cells : I. Theoretical diffusion models." Journal of Theoretical Biology 34(3): 451-467. <http://hdl.handle.net/2027.42/34150> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WMD-4F1Y9M7-B6/2/3b02b281a01be6943fc2f57ea6151177 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34150 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4668572&dopt=citation | en_US |
dc.description.abstract | Some general physical models are described for the diffusional transport of drugs across membranes of cells in culture suspensions. The models provide a basis for the design and analysis of experiments that are aimed to describe (a) the nature of the principal transport barrier, (b) the kinds of drug species being transported, (c) whether, where and how much solute binding occurs, and (d) the influences of pH, partition co-efficient and numerous other factors. The cell is treated as a sphere with non-homogeneous phase compartments. Both rigorous and approximate mathematical expressions have been derived for the quasi-steady-state diffusion through the membrane followed by three cases accounting for the distribution of drug in the heterogeneous cell interior, that is, (a) the non-steady-state situation, (b) establishment of instantaneous distribution and (c) instantaneous distribution in the aqueous interior with slow permeation of drug into the cytoplasmic bodies and nucleus. | en_US |
dc.format.extent | 3482690 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Systems approach to the study of drug transport across membranes using suspension cultures of mammalian cells : I. Theoretical diffusion models | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology, College of Pharmacy and Dental Research Institute, University of Michigan, Ann Arbor, Mich. 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Microbiology, College of Pharmacy and Dental Research Institute, University of Michigan, Ann Arbor, Mich. 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Microbiology, College of Pharmacy and Dental Research Institute, University of Michigan, Ann Arbor, Mich. 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Microbiology, College of Pharmacy and Dental Research Institute, University of Michigan, Ann Arbor, Mich. 48104, U.S.A. | en_US |
dc.identifier.pmid | 4668572 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34150/1/0000436.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-5193(72)90135-X | en_US |
dc.identifier.source | Journal of Theoretical Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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