Testosterone mediates satellite cell activation in denervated rat levator ani muscle
dc.contributor.author | Nnodim, Joseph O. | en_US |
dc.date.accessioned | 2006-04-19T13:26:51Z | |
dc.date.available | 2006-04-19T13:26:51Z | |
dc.date.issued | 2001-05-01 | en_US |
dc.identifier.citation | Nnodim, Joseph O. (2001)."Testosterone mediates satellite cell activation in denervated rat levator ani muscle." The Anatomical Record 263(1): 19-24. <http://hdl.handle.net/2027.42/34289> | en_US |
dc.identifier.issn | 0003-276X | en_US |
dc.identifier.issn | 1097-0185 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34289 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11331967&dopt=citation | en_US |
dc.description.abstract | Denervation stimulates quiescent satellite cells in skeletal muscle to reenter the cell cycle. In the androgen-sensitive rat levator ani muscle (LA), this mitotic response to loss of neural input fails to occur in castrated animals. To elucidate the role of androgens in denervation-induced satellite cell proliferation, the denervated LA of castrated rats (Group A) was compared with that of animals infixed with testosterone implants after castration (Group B). Mean myofiber cross-sectional areas (Group A: 362.95 Μm 2 ± 27.74; Group B: 403.13 Μm 2 ± 53.87) and linear nuclear densities (Group A: 74.07 mm −1 ± 17.58; Group B: 104.13 mm −1 ± 4.06) were similar ( P > 0.05) in both groups. The androgen-deprived myofibers of Group A, however, had a significantly lower nuclear content (271.0 ± 74.91 vs. 1,285.80 ± 81.74 in Group B; P < 0.05) on account of their considerably shorter mean length (3.44 mm ± 0.29 vs. 12.31 mm ± 0.92 in Group B; P < 0.05). The proportional representation of satellite cells in hormone-replaced, denervated muscle was more than twice that in the untreated group (Group B: 5.15 ± 0.83% vs. Group A: 2.28 ± 0.23%; P < 0.05). In absolute terms, the satellite cell number in Group B was approximately an order of magnitude greater than in Group A (408.4 × 10 3 vs. 38.08 × 10 3 ). The results confirm the absence of testosterone as the factor responsible for the inability of satellite cells in the LA of castrated rats to respond mitotically to the withdrawal of neural input after denervation. Anat Rec 263:19–24, 2001. © 2001 Wiley-Liss, Inc. | en_US |
dc.format.extent | 172218 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Testosterone mediates satellite cell activation in denervated rat levator ani muscle | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan ; Institute of Gerontology, University of Michigan, Rm. 913; 300 N. Ingallo Bldg., Box 2007, Ann Arbor, MI 48109-2007. Fax 734-936-2116 | en_US |
dc.identifier.pmid | 11331967 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34289/1/1072_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ar.1072 | en_US |
dc.identifier.source | The Anatomical Record | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.