Evidence of augmented central pain processing in idiopathic chronic low back pain
dc.contributor.author | Giesecke, Thorsten | en_US |
dc.contributor.author | Gracely, Richard H. | en_US |
dc.contributor.author | Grant, Masilo A. B. | en_US |
dc.contributor.author | Nachemson, Alf | en_US |
dc.contributor.author | Petzke, Frank W. | en_US |
dc.contributor.author | Williams, David A. | en_US |
dc.contributor.author | Clauw, Daniel J. | en_US |
dc.date.accessioned | 2006-04-19T13:27:51Z | |
dc.date.available | 2006-04-19T13:27:51Z | |
dc.date.issued | 2004-02 | en_US |
dc.identifier.citation | Giesecke, Thorsten; Gracely, Richard H.; Grant, Masilo A. B.; Nachemson, Alf; Petzke, Frank; Williams, David A.; Clauw, Daniel J. (2004)."Evidence of augmented central pain processing in idiopathic chronic low back pain." Arthritis & Rheumatism 50(2): 613-623. <http://hdl.handle.net/2027.42/34310> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34310 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14872506&dopt=citation | en_US |
dc.description.abstract | Objective For many individuals with chronic low back pain (CLBP), there is no identifiable cause. In other idiopathic chronic pain conditions, sensory testing and functional magnetic resonance imaging (fMRI) have identified the occurrence of generalized increased pain sensitivity, hyperalgesia, and altered brain processing, suggesting central augmentation of pain processing in such conditions. We compared the results of both of these methods as applied to patients with idiopathic CLBP (n = 11), patients with widespread pain (fibromyalgia; n = 16), and healthy control subjects (n = 11). Methods Patients with CLBP had low back pain persisting for at least 12 months that was unexplained by MRI/radiographic changes. Experimental pain testing was performed at a neutral site (thumbnail) to assess the pressure-pain threshold in all subjects. For fMRI studies, stimuli of equal pressure (2 kg) and of equal subjective pain intensity (slightly intense pain) were applied to this same site. Results Despite low numbers of tender points in the CLBP group, experimental pain testing revealed hyperalgesia in this group as well as in the fibromyalgia group; the pressure required to produce slightly intense pain was significantly higher in the controls (5.6 kg) than in the patients with CLBP (3.9 kg) ( P = 0.03) or the patients with fibromyalgia (3.5 kg) ( P = 0.006). When equal amounts of pressure were applied to the 3 groups, fMRI detected 5 common regions of neuronal activation in pain-related cortical areas in the CLBP and fibromyalgia groups (in the contralateral primary and secondary [S2] somatosensory cortices, inferior parietal lobule, cerebellum, and ipsilateral S2). This same stimulus resulted in only a single activation in controls (in the contralateral S2 somatosensory cortex). When subjects in the 3 groups received stimuli that evoked subjectively equal pain, fMRI revealed common neuronal activations in all 3 groups. Conclusion At equal levels of pressure, patients with CLBP or fibromyalgia experienced significantly more pain and showed more extensive, common patterns of neuronal activation in pain-related cortical areas. When stimuli that elicited equally painful responses were applied (requiring significantly lower pressure in both patient groups as compared with the control group), neuronal activations were similar among the 3 groups. These findings are consistent with the occurrence of augmented central pain processing in patients with idiopathic CLBP. | en_US |
dc.format.extent | 251701 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.title | Evidence of augmented central pain processing in idiopathic chronic low back pain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor ; University of Michigan, Chronic Pain & Fatigue Research Program, Division of Rheumatology, Department of Internal Medicine, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106 | en_US |
dc.contributor.affiliationother | Georgetown University, Washington, DC, and University of GÖteborg, GÖteborg, Sweden | en_US |
dc.contributor.affiliationother | University of Cologne, Cologne, Germany | en_US |
dc.identifier.pmid | 14872506 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34310/1/20063_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/art.20063 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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