Role of endoscopic ultrasonography in screening and treatment of pancreatic endocrine tumours in asymptomatic patients with multiple endocrine neoplasia type 1 Presented to the British Association of Endocrine Surgeons, Pisa, Italy, May 2002
dc.contributor.author | Gauger, Paul G. | en_US |
dc.contributor.author | Scheiman, James M. | en_US |
dc.contributor.author | Wamsteker, Erik-Jan | en_US |
dc.contributor.author | Richards, Melanie L. | en_US |
dc.contributor.author | Doherty, Gerard M. | en_US |
dc.contributor.author | Thompson, Norman W. | en_US |
dc.date.accessioned | 2006-04-19T13:30:01Z | |
dc.date.available | 2006-04-19T13:30:01Z | |
dc.date.issued | 2003-06 | en_US |
dc.identifier.citation | Gauger, P. G.; Scheiman, J. M.; Wamsteker, E.-J.; Richards, M. L.; Doherty, G. M.; Thompson, N. W. (2003)."Role of endoscopic ultrasonography in screening and treatment of pancreatic endocrine tumours in asymptomatic patients with multiple endocrine neoplasia type 1 Presented to the British Association of Endocrine Surgeons, Pisa, Italy, May 2002 ." British Journal of Surgery 90(6): 748-754. <http://hdl.handle.net/2027.42/34344> | en_US |
dc.identifier.issn | 0007-1323 | en_US |
dc.identifier.issn | 1365-2168 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34344 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12808627&dopt=citation | en_US |
dc.description.abstract | Background: Patients with multiple endocrine neoplasia (MEN) type 1 risk premature death from pancreatic endocrine tumours (PETs). Endoscopic ultrasonography (EUS) is the most sensitive imaging modality for small PETs. A screening and therapeutic approach for asymptomatic patients is delineated in which EUS plays a pivotal role. Methods: This was a retrospective study of 15 patients with MEN-1 but with no symptoms of a PET. All patients underwent serum hormone measurement, including gastrin, and EUS. The findings were used to facilitate operative treatment. Results: Six of 15 patients had a normal basal gastrin level and nine had a raised level. EUS demonstrated PETs in 14 patients and identified multiple lesions in 12. There was no predictive relationship between age or gastrin level and the number or size of PETs discovered. Thirteen patients have undergone enucleation or resection of PETs and two remain under observation. Nine of the 13 patients underwent transduodenal exploration to excise gastrinoma(s). One patient had lymph node metastases found at operation. There was no death. Self-limiting pancreatic fistula in five patients and biliary fistula in one. Conclusion: Early and aggressive screening using EUS identifies PETs in asymptomatic patients with MEN-1. Detection of tumours at an early stage, before the development of symptoms, lymph node metastases or liver metastases, may facilitate prompt surgical intervention and improve prognosis. Copyright © 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 822838 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Medicine | en_US |
dc.title | Role of endoscopic ultrasonography in screening and treatment of pancreatic endocrine tumours in asymptomatic patients with multiple endocrine neoplasia type 1 Presented to the British Association of Endocrine Surgeons, Pisa, Italy, May 2002 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Endocrine Surgery and Section of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA ; Department of Surgery, University of Michigan, 1500 East Medical Center Drive, TC2920H, Ann Arbor, Michigan 48109-0331, USA | en_US |
dc.contributor.affiliationum | Division of Endocrine Surgery and Section of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Endocrine Surgery and Section of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Endocrine Surgery and Section of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Endocrine Surgery and Section of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, University of Texas, San Antonio, Texas, USA | en_US |
dc.identifier.pmid | 12808627 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34344/1/4142_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bjs.4142 | en_US |
dc.identifier.source | British Journal of Surgery | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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