Trisomy 6 in basal cell carcinomas correlates with metastatic potential
dc.contributor.author | Nangia, Rina | en_US |
dc.contributor.author | Sait, Sheila N. J. | en_US |
dc.contributor.author | Block, Anne Marie W. | en_US |
dc.contributor.author | Zhang, Paul J. | en_US |
dc.date.accessioned | 2006-04-19T13:30:31Z | |
dc.date.available | 2006-04-19T13:30:31Z | |
dc.date.issued | 2001-05-15 | en_US |
dc.identifier.citation | Nangia, Rina; Sait, Sheila N. J.; Block, AnneMarie W.; Zhang, Paul J. (2001)."Trisomy 6 in basal cell carcinomas correlates with metastatic potential." Cancer 91(10): 1927-1932. <http://hdl.handle.net/2027.42/34355> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34355 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11346875&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Most basal cell carcinomas (BCCs) are indolent lesions; a few become locally aggressive or even metastatic. Little is known about the molecular and genetic alterations in this malignant transformation. Conventional karyotyping in BCC has revealed a high frequency of nonclonal, structural rearrangements, with few cases that show multiple, unrelated, small clones suggestive of a multicellular origin. Trisomy 6 was described recently in a few BCCs, but the biologic significance of the appearance of trisomy 6 in BBCs was not clear. METHODS Thirty cases including 4 metastatic, 4 locally aggressive, and 22 conventional nonaggressive BCCs were studied. Fluorescence in situ hybridization (FISH) was performed on 4 Μm tissue sections, using Α-centromeric enumeration probes for chromosome 6 (SpectrumGreen, Vysis Inc., Downers Grove, IL) and chromosome 4 (SpectrumOrange, Vysis Inc., Downers Grove, IL, used as disomic cell control). Trisomy 6 was semiquantitated within tumor cells and nonneoplastic cells in each case. RESULTS Trisomy 6 was identified in all 4 metastatic BCCs within tumor cells and in corresponding BCCs at the primary cutaneous site in 2 of these 4 cases. Two locally aggressive BCCs, 1 of which had preceding radiation exposure, also showed trisomy 6. All nonaggressive BCCs and nonneoplastic cells were disomic for chromosome 6. CONCLUSIONS Trisomy 6 has been identified as a cytogenetic aberration representative of tumor cells in aggressive and metastatic BCC. None of the nonaggressive BCCs in this study demonstrated trisomy 6. Acquisition of trisomy 6 by tumor cells in BCC may lead to the emergence of metastatic potential. Additional studies to define the underlying mechanisms may be valuable in preventing aggressive behavior in BCC. Cancer 2001;91:1927–32. © 2001 American Cancer Society. | en_US |
dc.format.extent | 243037 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Trisomy 6 in basal cell carcinomas correlates with metastatic potential | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan ; Fax: (734) 936-2756 ; Department of Pathology, The University of Michigan Medical School, 1301 Catherine Rd., Ann Arbor, MI 48109-0602 | en_US |
dc.contributor.affiliationother | Department of Pathology and Laboratory Medicine, Clinical Cytogenetics Laboratory, Roswell Park Cancer Institute, Buffalo, New York | en_US |
dc.contributor.affiliationother | Department of Pathology and Laboratory Medicine, Clinical Cytogenetics Laboratory, Roswell Park Cancer Institute, Buffalo, New York | en_US |
dc.contributor.affiliationother | Department of Pathology and Laboratory Medicine, Surgical Pathology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania | en_US |
dc.identifier.pmid | 11346875 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34355/1/1215_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/1097-0142(20010515)91:10<1927::AID-CNCR1215>3.0.CO;2-R | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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