Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions
dc.contributor.author | Su, Lyndon D. | en_US |
dc.contributor.author | Fullen, Douglas R. | en_US |
dc.contributor.author | Sondak, Vernon K. | en_US |
dc.contributor.author | Johnson, Timothy M. | en_US |
dc.contributor.author | Lowe, Lori | en_US |
dc.date.accessioned | 2006-04-19T13:30:59Z | |
dc.date.available | 2006-04-19T13:30:59Z | |
dc.date.issued | 2003-01-15 | en_US |
dc.identifier.citation | Su, Lyndon D.; Fullen, Douglas R.; Sondak, Vernon K.; Johnson, Timothy M.; Lowe, Lori (2003)."Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions." Cancer 97(2): 499-507. <http://hdl.handle.net/2027.42/34365> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/34365 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12518375&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Spindle and/or epithelioid melanocytic proliferations that display overlapping histopathologic features of Spitz nevus and Spitz-like melanoma are diagnostically difficult and controversial melanocytic tumors. There are reports of such lesions metastasizing to regional lymph nodes, with a few widely disseminating, resulting in death. METHODS The authors reviewed clinical and histopathologic data on all patients with atypical or borderline spitzoid melanocytic proliferations who underwent sentinel lymph node biopsy (SLNB). They examined how frequently histologically problematic or borderline spitzoid melanocytic lesions metastasized to sentinel lymph nodes (SLNs) and which clinical or histologic features, if any, predisposed patients to a higher risk lesion. RESULTS Six male patients and 12 female patients, ages 5–32 years (mean, 16 years), had tumors ranging in size from 1.2 mm to 7.9 mm (mean, 3.5 mm) in thickness. Atypical histologic features that were present most frequently included incomplete maturation (18 of 18 patients), deep dermal mitoses (16 of 18 patients), nuclear pleomorphism (10 of 18 patients), and focal sheet-like growth (10 of 18 patients). Eight of 18 patients (44%) had SLN metastasis and were offered adjuvant treatment. One of eight patients with SLN positive results who underwent regional lymphadenectomy had one additional involved lymph node. All 18 patients were alive and well with no evidence of recurrent or metastatic disease after a follow-up of 3–42 months (mean, 12 months). CONCLUSIONS Histologically atypical or borderline spitzoid, melanocytic tumors are diagnostically challenging and controversial melanocytic lesions, some of which represent unrecognized melanomas. SLNB aids in confirming a diagnosis of melanoma and identifies patients who may benefit from early therapeutic lymph node dissection and/or adjuvant therapy. Cancer 2003;97:499–507. © 2003 American Cancer Society. DOI 10.1002/cncr.11074 | en_US |
dc.format.extent | 909489 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan ; Fax: (734) 936-2756 ; Department of Pathology, Division of Dermatopathology, University of Michigan Medical Center, Medical Sciences I, M5224, 1301 Catherine Street, Ann Arbor, MI 48109-0602 | en_US |
dc.contributor.affiliationum | Department of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Dermatology, Otorhinolaryngology, and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 12518375 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/34365/1/11074_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.11074 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.